Registration Dossier
Registration Dossier
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EC number: 940-273-1 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Acute toxicity of formic acid in mice and rats is reported in the "BUA Stoffbericht No. 81".
These data were used as read-across source for "Stabilizer for Cyanamide F1000".
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 700 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 in the mouse after oral application is 700 mg/kg BW.
- Executive summary:
The LD50 in the mouse after oral application is 700 mg/kg BW.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 830 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 in the rat after oral application is 1830 mg/kg BW.
- Executive summary:
The LD50 in the rat after oral application is 1830 mg/kg BW.
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- The multiconstituent substance "Stabilizer for Cyanamid F1000" contains up to 8 % formic acid.
Formic acid is the constituent relevant for C&L of the multiconstituent stabilizer. - Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Species:
- other: rat and mouse
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 830 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Rat
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 700 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Mouse
- Interpretation of results:
- GHS criteria not met
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 700 mg/kg bw
Additional information
Justification for classification or non-classification
The multiconstituent substance "Stabilizer for Cyanamid F1000" contains up to 7 % formic acid.
Formic acid is the constituent relevant for C&L of the multiconstituent stabilizer.
As formic acid shows an LD50 between 700 mg/kg BW (mouse) and 1830 mg/kg BW (rat), the "Stabilizer for Cyanamide F1000" has to be classified as "harmful if swallowed (H302, acute toxic cat. 4)" according to CLP-Regulation.
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