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Administrative data

Description of key information

Acute toxicity of formic acid in mice and rats is reported in the "BUA Stoffbericht No. 81".

These data were used as read-across source for "Stabilizer for Cyanamide F1000".

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1991
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
other: not specified
Species:
mouse
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 700 mg/kg bw
Based on:
test mat.
Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 in the mouse after oral application is 700 mg/kg BW.
Executive summary:

The LD50 in the mouse after oral application is 700 mg/kg BW.

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1991
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
other: not specified
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 1 830 mg/kg bw
Based on:
test mat.
Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 in the rat after oral application is 1830 mg/kg BW.
Executive summary:

The LD50 in the rat after oral application is 1830 mg/kg BW.

Endpoint:
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
The multiconstituent substance "Stabilizer for Cyanamid F1000" contains up to 8 % formic acid.
Formic acid is the constituent relevant for C&L of the multiconstituent stabilizer.
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Species:
other: rat and mouse
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 1 830 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Rat
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 700 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Mouse
Interpretation of results:
GHS criteria not met
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
700 mg/kg bw

Additional information

Justification for classification or non-classification

The multiconstituent substance "Stabilizer for Cyanamid F1000" contains up to 7 % formic acid.

Formic acid is the constituent relevant for C&L of the multiconstituent stabilizer.

As formic acid shows an LD50 between 700 mg/kg BW (mouse) and 1830 mg/kg BW (rat), the "Stabilizer for Cyanamide F1000" has to be classified as "harmful if swallowed (H302, acute toxic cat. 4)" according to CLP-Regulation.