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Administrative data

Description of key information

Formic acid causes mild skin irritation in an open skin irritation test according to RTECS.

A study to assess eye irritation does not need to be conducted (see 'justification for data waiving' in the relevant study record).

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Referenceopen allclose all

Endpoint:
skin corrosion: in vitro / ex vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
an in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1992
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
no guideline available
Principles of method if other than guideline:
Open irritation test according to RTECS update 9001.
GLP compliance:
not specified
Species:
rabbit
Type of coverage:
open
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
610 mg
Duration of treatment / exposure:
not specified
Observation period:
not specified
Number of animals:
not specified
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
ca. 1
Reversibility:
not specified
Remarks on result:
probability of mild irritation
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
ca. 1
Reversibility:
not specified
Remarks on result:
probability of mild irritation
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
ca. 2
Reversibility:
not specified
Remarks on result:
probability of mild irritation
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
ca. 1
Reversibility:
not specified
Remarks on result:
probability of mild irritation
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
ca. 1
Reversibility:
not specified
Remarks on result:
probability of mild irritation
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
ca. 2
Reversibility:
not specified
Remarks on result:
probability of mild irritation
Interpretation of results:
GHS criteria not met
Conclusions:
According to RTECS formic acid causes mild skin irritation.
Executive summary:

According to RTECS formic acid causes mild skin irritation.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vitro / ex vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is classified as skin irritation and the available information indicates that it should be classified as eye irritation (Category 2)

Additional information

Justification for classification or non-classification

The available information indicates that the criteria are met for classification as irritating to the skin or irritating to eyes.

The multiconstituent substance Stabilisator for Cyanamid contains < 8 % formic acid. Therefore the substance is classified as Skin Irrit. 2 (H315) and Eye Irrit 2 (H319).