1-(3-chloropyridin-2-yl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]-3-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl}-1H-pyrazole-5-carboxamide

Melting point / freezing point

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

7 May 2013

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

GLP compliance:

yes (incl. QA statement)

Remarks:

Hess, Ministerium für Umwelt, Energie, Landwirtschaft und Verbraucherschutz, Wiesbaden, Germany

Type of method:

differential scanning calorimetry

Key result

Melting / freezing pt.:

>= 226.9 - <= 229.6 °C

Atm. press.:

1 013 hPa

The measurements in aluminium crucibles with a hole showed an endothermal effect in the temperature range of 210 - 240 °C with an onset temperature of 227 °C to 230 °C. An exothermal effect was observed in the temperature range of 240 - 495 °C with an energy of 934 J/g and 1470 J/g, respectively. The onset temperature was derived from the intersection of the tangent line with the highest slope of the endothermal peak with the baseline.

The test item had a melting range of 226.9 °C to 229.6 °C.

Ident-No.	Onset / °C	Temperature range / °C	Crucible
33742	226.89	210 to 240	Aluminium with a hole
33743	229.56	210 to 240	Aluminium with a hole

Reference 2

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

17 to 24 November 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

GLP compliance:

yes (incl. QA statement)

Remarks:

Hess, Ministerium für Umwelt, Energie, Landwirtschaft und Verbraucherschutz, Wiesbaden, Germany

Type of method:

differential scanning calorimetry

Key result

Melting / freezing pt.:

>= 228.4 - <= 230.1 °C

Atm. press.:

ca. 1 013 hPa

Three measurements in aluminium crucibles with a hole showed an endothermal effect in the temperature range of 205 - 245 °C with onset temperatures of 228.42 °C - 230.06 °C. The results are summarized in the table below.

 

Melting point (DSC measurement)

Ident No.	Test item / mg	Measurement range / °C	Temperature range / °C	Type of effect	Onset / °C	Remarks
35321	9.39	Ambient temperature - 400	205 -245 245 - 365	endethermal exothermal	230.06 n.r.	aluminium crucible with a hole; mass loss: 3.77 mg; discoleured to black
35323	9.52	Ambient temperature - 400	210 - 240 240 - 360	endethermal exothermal	228.42 n.r.	aluminium crucible with a hole; mass loss: 3.71 mg; discoleured to black
35353	10.04	Ambient temperature - 240	210 - 240	endethermal	228.66	aluminium crucible with a hole; no mass loss; orange melt

n.r.: not relevant

 

The test item had a melting range under decomposition of 228.4 - 230.1 °C.

Description of key information

Melting range: 226.9 °C to 229.6 °C (pure substance) - 228.4 - 230.1 °C (technical substance)

(OECD Guideline 102, DSC measurement)

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

228.4 °C

Additional information

The lower value of the melting range for technical substance has been selected as key value. Technical purity represents better the reality and the lower temperature value has been selected as the "worst case".