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EC number: 810-161-6 | CAS number: 1229654-66-3
Endpoint summary
Administrative data
Description of key information
Not readily biodegradable according to the OECD criteria
(1% degradation after 28 d, OECD 301 F), M-571269-01-1
Aerobic Aquatic Water/Sediment Systems (OECD 308):
DT50 water: 5.3 - 6.3 days at 20.3 °C , M-492584-01-1
DT50 water/sediment: 11.1 - 122 days at 20.3 °C , M-492584-01-1
Anaerobic Aquatic Water/Sediment Systems: (OECD 308):
DT50 water: 16 - 24.1 days at 20.1 °C, M-546847-01-2
DT50 water/sediment: 104 - 218 days at 20.1 °C, M-546847-01-2
Aerobic Aquatic Mineralization in Surface Water (OECD 309):
DT50 water: 0.9 days at 20.5 °C, M-545815-01-2
Aerobic Biodegradation in soil (OECD 307):
DT50 soil: 18.4 - 183 days at 20 °C, M-465975-02-1
Anaerobic Biodegradation in soil (OECD 307):
DT50 soil: 79 - 124 days at 20 °C, M-478837-01-1
Remark: Since its 32nd meeting the Member State Committee has started to require new simulation degradation studies to be carried out around neutral pH values and at 12 ˚C, which is understood as the mean temperature of European surface waters (ECHA 2014: Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.11). None of the present biodegradation studies has been performed at 12 °C and the determined degradation rates were not extrapolated to European mean temperature.
Additional information
Screening test on ready biodegradability
In a biodegradation screening study according to OECD 301 F the substance was found to be not readily biodegradable under the test conditions at the end of the 28-day exposure period (M-571269-01-1).
Aerobic Aquatic Water/Sediment Systems
The substance dissipated rapidly from the water in water/sediment systems under aerobic conditions (M-492584-01-1, M-492584-01-1). The calculated DT50 values for the dissipation from water were 5.3 and 6.3 days. In the total test system, the calculated DT50 values were 11.1 and 122 days for the total system.
Two degradation products were identified with the following maximum occurrences in the total water/sediment system: [test substance]-N methyl-quinazolinone with 84.8%AR and [test substance]- methyl-quinazolinone-amide with 9.2%AR.
Formation of non-extractable residues (NER) was up to 12.1%AR at DAT-29, which is an indication for biotic degradation. Degradation rates were higher in systems where the pH was more alkaline, illustrating the importance of abiotic hydrolysis in the degradation pathway.
Anaerobic Aquatic Water/Sediment Systems
The substance degrades in anaerobic aquatic test systems with half-lives in water ranging from 16.0 to 24.1 days and in the total system from 104 to 218 days (M-546847-01-2). [Test substance]- N-methyl-quinazolinone was characterized as major degradation product. This metabolite reached 19.5% and 44.0% at the end of the 104-day study, occurring primarily in the sediment. The substance will not persist under anaerobic aquatic conditions. Degradation rates were higher in systems where the pH was more alkaline, illustrating the importance of abiotic hydrolysis in the degradation pathway.
Aerobic Aquatic Mineralization in Surface Water
The DT50 values for the test substance in the tested surface water under aerobic conditions were 0.9 days (M-545815-01-2). Formation of carbon dioxide was insignificant during the test, indicating that mineralization plays only a minor role in the fate of the test substance in surface water under the conditions of the test.
Aerobic Biodegradation in Soil
The substance was moderately degraded in soil under aerobic conditions in the dark in the laboratory (M-465975-02-1). Its calculated half-lives ranged between 18.4 and 183 days. Formation of carbon dioxide was observed up to 2.5%AR at study end.
Besides carbon dioxide, six major degradation products were detected: [test substance]-quinazolinone-carboxylic acid, [test substance]-N-methyl-quinazolinone, [test substance]-amide, [test substance]-carboxylic acid, [test substance]-desmethyl-amide-carboxylic acid and [test substance]-methyl-quinazolinone-carboxylic acid. Formation of non-extractable residues was up to a maximum of 13.9%AR.
The formation of carbon dioxide indicates the potential for mineralization of the test item and its transformation products. Therefore, the substance is not expected to have a potential for accumulation in the environment.
Anaerobic Biodegradation in Soil
The substance was moderately degraded in soil under anaerobic conditions in the dark in the laboratory (M-478837-01-1). The calculated half-lives under anaerobic conditions ranged between 79 and 124 days.
Formation of carbon dioxide was observed up to 0.4%AR during the aerobic incubation phase.
Three major degradation products were detected: [test substance]-carboxylic acid, [test substance]-N-methyl-quinazolinone and [test substance]-methyl-quinazolinone-carboxylic acid. Formation of non-extractable residues was a maximum of 5.5%AR at the end of the aerobic incubation phase and increased to a maximum of 10.4%AR during the anaerobic incubation phase.
The results indicate that the substance is not expected to have a potential for accumulation in the terrestrial environment.
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