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Diss Factsheets
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EC number: 230-811-7 | CAS number: 7328-17-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://www.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to OECD 404 and conducted according to GLP of the US EPA, CFR Part 792
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- small deviations
- Principles of method if other than guideline:
- no step-wise approach used, 6 animals used
exposed skin area 10 cm2 instead of 6 cm2 - GLP compliance:
- yes
Test material
- Reference substance name:
- SR 256, HXF 0946; no further ID of test substance
- IUPAC Name:
- SR 256, HXF 0946; no further ID of test substance
- Test material form:
- other: liquid
- Details on test material:
- - Clear liquid
- Used as received
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Six healthy New Zeland Albino rabbits ( 3 males and 3 females ) 2.0 -2,.4 kg bw were individually caged with a light/dark cycle of 12 hours under temperture controlled conditions.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml of the test article was applied.
- Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 14 days;
Observation points: > 1hrs , 24 hrs, 48 hrs, 72 hrs, 7 d, 14d - Number of animals:
- 6: 3 males and 3 females
- Details on study design:
- similar to OECD 404
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 30 min to 1 hrs
- Score:
- 1
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 hrs
- Score:
- 0.83
- Max. score:
- 1
- Remarks on result:
- other: 1/6 brown areas on the skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48 hrs
- Score:
- 1.67
- Max. score:
- 2
- Remarks on result:
- other: 1/6 brown areas on the skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 hrs
- Score:
- 1.67
- Max. score:
- 2
- Remarks on result:
- other: 1/6 brown areas on the skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 2.5
- Max. score:
- 4
- Remarks on result:
- other: 5/6 flaking skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: day 14
- Score:
- 0.5
- Max. score:
- 1
- Remarks on result:
- other: 1/6 poor hair regrowth, 2/6 flaking skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 30 min to 1 hr
- Score:
- 3.33
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 hrs
- Score:
- 2.83
- Max. score:
- 3
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48 hrs
- Score:
- 2.17
- Max. score:
- 3
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 hrs
- Score:
- 1.83
- Max. score:
- 2
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 7 d
- Score:
- 1.66
- Max. score:
- 2
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 14 d
- Score:
- 0.5
- Max. score:
- 1
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
Under the conclusion of this study, the test article is an irritant but not corrosive and thus fulfill the CLP-classification criteria as Skin Irrit 2, H315.- Executive summary:
Six healthy New Zeland Albino rabbits ( 3 males and 3 females ) were dosed dermally with SR 256 HXF 0946. 0.5 ml of test article was applied under semi-occlusive conditions on intact clipped skin. The test article was kept in contact with the skin for 4 hours. Draize scoring was performed after ½-1, 24, 48, 72 hours and 7 and 14 days. The scoring indicated the substance to be a moderate to severe irriatant but not a corrosive as irreversible damage and necrosis was not observed.
According to the CLP-criteria the substance should be classified as Skin Irrit 2, H315.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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