Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

in vivo mammalian germ cell study: cytogenicity / chromosome aberration
Justification for type of information:
The positive findings in vitro where Ethoxy ethoxy ethyl acrylate (CAS No. 7328-17-8) demonstrated marked toxicity and induced statistically significant increases in the frequency of cells with chromosome aberrations, in both the absence and presence of a liver enzyme metabolizing system (S9) and thus was considered to be clastogenic to human lymphocytes in vitro, needs to be further evaluated in vivo. In accordance to ECHA guidance R7A (version 6.0, 2017); in case of negative OECD 471 and positive OECD 473, no OECD 476 (HPRT) is needed, and a testing proposal should be proposed (appropriate in vivo study). Thus an in vivo chromosome aberration test (OECD 474) is proposed.

Data source

Materials and methods

Test guideline
according to guideline
OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
Version / remarks:
Testing proposal based on positive findings in vitro (OECD 473)

Results and discussion

Applicant's summary and conclusion