1,1-dimethoxy-2-phenylethane

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

30-Nov-2015 to 04-Dec-2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Remarks:

Staatliches Gewerbeaufsichtsamt Hildeshelm

Type of method:

flask method

Key result

Water solubility:

3.9 g/L

Temp.:

20 °C

pH:

4.7

Results

Preliminary Test (non GLP)

The solubility was determined to be in the range of 2.06 - 4.12 g/L; no Tyndall-effect was observed at 2.06 g/L. For the application dose for the definitive study, approx. 20 g/L, as ca. the fivefold of the maximum solubility result, was used.

 

Main test

Water solubility results at 20 °C

Pre-incubation time	Replicate No.	Concentration^1) (g/L)	Mean
24 h	1	3.95	3.94
	2	3.94
48 h	1	3.92	3.86
	2	3.80
72 h	1	3.90	3.91
	2	3.91
Mean (24 – 72 h)			3.90
Deviation (%)^2)			2.1

 

1) Mean value of double injections, dilution factor of 200 and exact weights taken into account

2) Calculated according to the formula:

Deviation (%) =100 x (max value – min value)

                                      min value

Mean pH value = 4.7

Conclusions:

A water solubility value of 3.90 g/L (at 20 °C, pH 4.7) was determined for the test substance according to E.U. Method A.6.

Description of key information

Water solubility: 3.90 g/L at 20 °C, pH = 4.7 (EU Method A.6., flask method)

Key value for chemical safety assessment

Water solubility:

3.9 g/L

at the temperature of:

20 °C