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EC number: 202-945-6 | CAS number: 101-48-4
The acute oral toxicity of the test substance was assessed in a study according to OECD Guideline 423 and in compliance with GLP (2015a). In a first step, a total dose of 2000 mg/kg bw of the test substance diluted in corn oil was administered to 3 female rats. Animals were observed 0.5, 1, 2, 4 and 6 hours after dosing and subsequently once daily for 14 days. Individual body weights were recorded prior to dosing on Day 0 and on Days 1, 3, 7 and on the day of necropsy, Day 14. Macroscopic examination was performed at the end of the observation period at terminal sacrifice. In a second step, 3 additional female rats were treated with 2000 mg/kg bw of the test substance diluted in corn oil. No mortalities were observed at 2000 mg/kg bw until the end of the study. Abnormal gait was evident in 2 animals at 1 and 2 hours after dosing. The sign disappeared 4 hours after dosing. All animals showed expected gains in body weight over the study period and no abnormalities were noted at necropsy. Based on the results of this study, the LD50 value was determined to be > 2000 mg/kg bw in rats. In accordance with OECD Guideline 423, Annex 2d, a cut-off value of≥5000 mg/kg bw was derived, since no mortality occurred at 2000 mg/kg bw.
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