Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 435-580-8 | CAS number: 56553-60-7
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.526 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 264.5 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- No data on testing of inhalation toxicity is available, thus extrapolation from oral route is applicable.
- AF for dose response relationship:
- 1
- Justification:
- Default value according to ECHA REACH Guidance R.8.
- AF for differences in duration of exposure:
- 6
- Justification:
- Default value according to ECHA REACH Guidance R.8.
- Justification:
- Default value according to ECHA REACH Guidance R.8.
- AF for intraspecies differences:
- 5
- Justification:
- Default value according to ECHA REACH Guidance R.8.
- AF for the quality of the whole database:
- 1
- Justification:
- Default value according to ECHA REACH Guidance R.8.
- AF for remaining uncertainties:
- 2.5
- Justification:
- Default value according to ECHA REACH Guidance R.8.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
- DNEL extrapolated from long term DNEL
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 10 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 30
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 3 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- No data on testing of long-term dermal toxicity is available, thus extrapolation from oral route is applicable.
- AF for dose response relationship:
- 1
- Justification:
- Default value according to ECHA REACH Guidance R.8.
- AF for differences in duration of exposure:
- 6
- Justification:
- Default value according to ECHA REACH Guidance R.8.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default value according to ECHA REACH Guidance R.8.
- AF for other interspecies differences:
- 1
- Justification:
- Default value according to ECHA REACH Guidance R.8.
- AF for intraspecies differences:
- 5
- Justification:
- Default value according to ECHA REACH Guidance R.8.
- AF for the quality of the whole database:
- 1
- Justification:
- Default value according to ECHA REACH Guidance R.8.
- AF for remaining uncertainties:
- 2.5
- Justification:
- Default value according to ECHA REACH Guidance R.8.
Acute/short term exposure
- Hazard assessment conclusion:
- no DNEL required: short term exposure controlled by conditions for long-term
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Since consumer uses are not foreseen, a derivation of consumer DNEL is not applicable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
