Registration Dossier
Registration Dossier
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EC number: 277-225-8 | CAS number: 73018-51-6 The complex combination of hydrocarbons obtained by the acid isomerization of linalool. It consists primarily of monoterpenes, terpene alcohols and oxygenated cyclic compounds.
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Lime Oxide
- IUPAC Name:
- Lime Oxide
- Reference substance name:
- 1,6-Octadien-3-ol, 3,7-dimethyl-, acid-isomerized
- EC Number:
- 277-225-8
- EC Name:
- 1,6-Octadien-3-ol, 3,7-dimethyl-, acid-isomerized
- Cas Number:
- 73018-51-6
- IUPAC Name:
- 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized
- Reference substance name:
- Reaction mass of (E)-5-(but-2-en-2-yl)-2,2-dimethyltetrahydrofuran and 1-isopropyl-4-methylcyclohexa-1,3-diene and 1-isopropyl-4-methylcyclohexa-1,4-diene and 1-methyl-4-(propan-2-ylidene)cyclohex-1-ene
- IUPAC Name:
- Reaction mass of (E)-5-(but-2-en-2-yl)-2,2-dimethyltetrahydrofuran and 1-isopropyl-4-methylcyclohexa-1,3-diene and 1-isopropyl-4-methylcyclohexa-1,4-diene and 1-methyl-4-(propan-2-ylidene)cyclohex-1-ene
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Lime Oxide
- Molecular formula: predominantly a mixture of monoterpenes C10H16 and cyclic monoterpene ethers C10H18O
- Molecular weight: monoterpenes C10H16 molecular weight 136.2, cyclic monoterpene ethers C10H18O molecular weight 154.2
- Physical state: clear colorless liquid
- Analytical purity: 61.8%, sum of 4 major peaks
- Impurities: Known impurities are similar in nature to the major components and have empirical formulae of either C10H16 or C10H18O
- Lot/batch No.: SC00009577
- Expiration date of the lot/batch: 13 October 2015
- Storage condition of test material: room temperature, in the dark
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Six days acclimatation.
Unique identification.
Aluminium cages with grid floors.
Environmental max was 21'C and min 20'C and relative humidity was 54%.
A 12h ligh dark cyle.
Standard rabbit diet.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- not specified
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48, 72 hours and 14 days.
- Number of animals:
- 3 male rabbits
- Details on study design:
- 0.5 mL of test material was applied to the intact skin on each rabbit under 2.5 cm x 2.5 cm patches of gauze. The patches were then covered with micopore tape and the trunk was loosly bound with Elastoplast Elastic Bandage with remiained in position for 4 hours. At the end of this period the patches were removed and the skin wiped to remove surplus test material without altering the existing response or the integrity of the epidermis.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: NA
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 12 days
- Remarks on result:
- probability of weak irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the study, Lime Oxide Hydrogenated is slightly irritant to rabbit skin.
- Executive summary:
Slighy skin irritation observed, insufficient signs for classification.
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