1,6-Octadien-3-ol, 3,7-dimethyl-, acid-isomerized

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1995

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1995

Report date:

1995

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)

Deviations:

no

GLP compliance:

yes

Test type:

fixed dose procedure

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Lime Oxide

IUPAC Name:

Lime Oxide

Constituent 2

Reference substance name:

1,6-Octadien-3-ol, 3,7-dimethyl-, acid-isomerized

EC Number:

277-225-8

EC Name:

1,6-Octadien-3-ol, 3,7-dimethyl-, acid-isomerized

Cas Number:

73018-51-6

IUPAC Name:

1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized

Constituent 3

Reference substance name:

Reaction mass of (E)-5-(but-2-en-2-yl)-2,2-dimethyltetrahydrofuran and 1-isopropyl-4-methylcyclohexa-1,3-diene and 1-isopropyl-4-methylcyclohexa-1,4-diene and 1-methyl-4-(propan-2-ylidene)cyclohex-1-ene

IUPAC Name:

Reaction mass of (E)-5-(but-2-en-2-yl)-2,2-dimethyltetrahydrofuran and 1-isopropyl-4-methylcyclohexa-1,3-diene and 1-isopropyl-4-methylcyclohexa-1,4-diene and 1-methyl-4-(propan-2-ylidene)cyclohex-1-ene

Test material form:

other: liquid

Details on test material:

- Name of test material (as cited in study report): Lime Oxide
- Molecular formula: predominantly a mixture of monoterpenes C10H16 and cyclic monoterpene ethers C10H18O
- Molecular weight: monoterpenes C10H16 molecular weight 136.2, cyclic monoterpene ethers C10H18O molecular weight 154.2
- Physical state: clear colorless liquid
- Analytical purity: 61.8%, sum of 4 major peaks
- Impurities: Known impurities are similar in nature to the major components and have empirical formulae of either C10H16 or C10H18O
- Lot/batch No.: SC00009577
- Expiration date of the lot/batch: 13 October 2015
- Storage condition of test material: room temperature, in the dark

Specific details on test material used for the study:

The study report states that Lime Oxide is Hydrogenated.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Dose ranging rats were were housed singly and main study rats were housed 5 to a cage by sex.
The mean environmental maximum and minimum temperatures during the main study were 22'C and 20'C, respectively and mean relative humidity was 59%.
A 12 hour light/dark cycle was in operation with 15-20 air changes per hour.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

maize oil

Details on oral exposure:

The test material was administered orally in a single dose by means of a gavage at a constant dose volume of 10 mL/kg.

Doses:

Dose Range: 5, 50, 500 and 2000 mg/kg.
Main: One group of males and females were dosed at 2000 mg/kg.

No. of animals per sex per dose:

5 males and 5 females.

Control animals:

no

Statistics:

Not required as there were no clinical observations.

Results and discussion

Preliminary study:

No clinical observations.

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

not determinable due to absence of adverse toxic effects

Mortality:

No mortality observed.

Clinical signs:

other: No clinical observations.

Gross pathology:

No gross pathology observated.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Under the conditions of the study, the LD50 is greater than 2000 mg/kg.
As no clinical signs or mortality was observed, no classification is required.

Executive summary:

Under the conditions of the study, the LD50 is greater than 2000 mg/kg.