Registration Dossier
Registration Dossier
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EC number: 277-225-8 | CAS number: 73018-51-6 The complex combination of hydrocarbons obtained by the acid isomerization of linalool. It consists primarily of monoterpenes, terpene alcohols and oxygenated cyclic compounds.
Toxicological information
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 7.05 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 37.5
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 264.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for differences in duration of exposure:
- 3
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 5
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 21.16 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 12.5
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 264.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 5
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 17.63 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 15
- Dose descriptor:
- NOAEC
- Value:
- 264.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for differences in duration of exposure:
- 3
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 1
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 5
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 52.89 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 5
- Dose descriptor starting point:
- NOAEC
- Value:
- 264.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 1
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 5
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 150
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for differences in duration of exposure:
- 3
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 5
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 5
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4.41 mg/cm²
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 60
- Dose descriptor:
- NOAEC
- Value:
- 264.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for differences in duration of exposure:
- 3
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 1
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 5
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 13.23 mg/cm²
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 20
- Dose descriptor starting point:
- NOAEC
- Value:
- 264.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 1
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 5
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.74 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 130.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for differences in duration of exposure:
- 3
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 10
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5.22 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 130.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 10
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4.35 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 30
- Dose descriptor:
- NOAEC
- Value:
- 130.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for differences in duration of exposure:
- 3
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 1
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 10
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 13.04 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 10
- Dose descriptor starting point:
- NOAEC
- Value:
- 130.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 1
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 10
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for differences in duration of exposure:
- 3
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 10
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 10
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.09 mg/cm²
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 120
- Dose descriptor:
- NOAEC
- Value:
- 130.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for differences in duration of exposure:
- 3
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 1
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 10
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.26 mg/cm²
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 40
- Dose descriptor starting point:
- NOAEC
- Value:
- 130.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 1
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 10
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for differences in duration of exposure:
- 3
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 10
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.31 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- ECHA Default Assessment
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA Default Assessment
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA Default Assessment
- AF for intraspecies differences:
- 10
- Justification:
- ECHA Default Assessment
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Default Assessment
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Default Assessment
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
