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EC number: 922-670-1 | CAS number: -
- complex metal containing substance- classification made based on CLP mixture toxicity rules- solubility of metal constituents is poor
The calculated classification via mixture toxicity rules resulted in “Carcinogenicity Category 1A H350” because of the presence of Arsenic acid and its salts.
Results from calculated classification (using mixture toxicity rules) are supported (WoE) by additional consideration from phys chem properties of the UVCB substance.
The UVCB is a complex metal containing substance , which major constituents are sulphuric acic and water. Sulphuric acid is a strong mineral acid that has high affinity to water. It dissociates in water to form sulphate and hydrogen (carbonium) ions. These are the relevant forms to determine hazard properties of the substance. Arsenic was the only constituent with concentration >0.1%, this constituent triggers the toxicity of the substance. The maximum across industry were taken to derive the classification of the UVCB.
Carcenogenicity Cat 1A H350
The classification derived is applicable to all Sulphuric acid, waste gas cooling and cleaning, copper smelting.
The tested sample is representative for a worst case , defined within the concentration ranges outlined under IUCLID section 1.2
Self-classification of the UVCB substance (IUCLID Section 2.1 & 2.2) was performed based on below outline:
the material is accurately described from its elemental/chemical composition (concentration ranges across production sites –IUCLID Section 1.2), and the specific speciation data (mineralogical information, hazard) obtained from a representative sample (IUCLID Section 4, in particular 4.23). This information is enough to initiate the classification process.
2. Classification by the Mixture Approach
The UVCB is treated as a complex metal containing substance with a number of discrete constituting compounds (metals, metal compounds, non-metal inorganic compounds). The hazard classifications of each compound is then factored into a combined classification of the UVCB as a whole. For health endpoints, UVCB classifications are based on the combined hazards of the compounds whereby additivity or key cut off levels, specified in look-up tables are used, depending on the endpoint and amount of information available for the constituting compounds. For environmental endpoints, additivity and/or summation algorithms are applied to quantitatively estimate the mixture’s toxicity to aquatic organisms. These concepts and rules are incorporated in easy to use IT tools, which can be used to classify the UVCB.
3. Bridging or Read-Across
(Eco)-toxicological data are not available for the specific UVCBs being evaluated. Considering the knowledge and variability in composition, read-across and bridging is done by using a "representative" mineralogical/speciation analysis" combined with the "worst case" metal concentration (across companies) as a basis for the classification of the UVCB substance (chemical and mineralogical surrogates with similar origin/production process and physical/chemical properties –see IUCLID 1.4 for information on Sampling procedure).
4. Eventual correction
No correction for (bio)availability was made
See furthermore attached documents:
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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