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EC number: 942-401-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 July 2016 - 28 October 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Exposure concentrations were not analytically verified.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 23 (OECD series on testing and assessment guidance document on aquatic toxicity testing of difficult substances and mixtures.)
- Version / remarks:
- 2000
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Bismuth oxy-iodide bromide
- Cas Number:
- 340181-06-8
- Molecular formula:
- BiOIxBr(1-x), with x = 0.4 - 0.85
- IUPAC Name:
- Bismuth oxy-iodide bromide
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Appearance: orange powder
- Storage condition of test material: room temperature
Constituent 1
- Specific details on test material used for the study:
- Solubility in water: < 1 mg/L (see section 4.8 for details)
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- REPARATION AND APPLICATION OF TEST SOLUTION
- Method: WAFs were prepared seperately for each test concentration and stirred for 7 days. At the end of the stirring period, the magnetic stirrers were stopped and the test substance was allowed to settle. WAF solutions were filtered (0.45 µm). The filtered WAF solutions were transferred to the glass aquaria for the final study.
- Controls: medium without test item
- Evidence of undissolved material: not indicated
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebrafish
- Strain: not indicated
- Source: registered animal facility (no further details provided)
- Age at study initiation: not indicated
- Weight at study initiation: mean weight of 0.229 g for individual fish
- Length at study initiation: not indicated, however the weight of the fish corresponds to the length-range prescribed by OECD 203 (2.0 +/- 1.0 cm)
- Method of breeding: not indicated
ACCLIMATION
- Acclimation period: 10 days
- Acclimation conditions: same as test
- Type and amount of food during acclimation: not indicated
- Health during acclimation: no mortalities or other indications of disease were observed
FEEDING DURING TEST: no
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
Test conditions
- Hardness:
- 272.46 mg CaCO3/L
Start: 14.00 - 16.00 dH
End: 16.00-16.80 dH - Test temperature:
- Start: 24.7 - 25.0 °C
End: 25.4 - 25.7 °C - pH:
- Start: 7.5 - 8.1
End: 7.5 - 8.0 - Dissolved oxygen:
- Start: 96 - 100 %
End: 96 - 98 % - Conductivity:
- Start: 730 - 747 µs/cm
End: 758 - 776 µs/cm - Nominal and measured concentrations:
- Nominal test concentrations: 62.5, 125, 250, 500 and 1000 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 10 litre, glass aquaria with transparent cover , fill volume: 7 litres
- Aeration: glass pipette
- Renewal rate of test solution: no
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.2 g/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: not indicated
- Culture medium different from test medium: not indicated
- Intervals of water quality measurement: 24 h
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod:14 hours light, 10 hours dark
- Light intensity: not indicated
EFFECT PARAMETERS MEASURED: mortality after 96 hours. In addition, pH, temperature, oxygen, conductivity and hardness at the start and end of the fish exposure period in all aquaria were measured.
TEST CONCENTRATIONS
- Range finding study: nominal test concentrations were based on a preliminary test, no further details were provided - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Remarks on result:
- other: The 96-h LC50 was determined to be above the maximum solubility in test media.
- Details on results:
- - No mortality was observed in any of the tested concentrations.
- No behavioural, biological or other abnormalities were observed
- Effect concentrations exceeding solubility of substance in test medium: yes
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- For details on validity criteria see 'Overall Remarks' section
- Conclusions:
- No mortality at any of the tested concentrations was observed, therefore the 96h-LC50 was determined to be above the maximum solubility of the test substance in test media. The test substance is concluded not to be acute toxic to fish at its maximum solubility in test media.
- Executive summary:
In a 96 -h acute toxicity study conducted according to OECD guideline 203 and GLP principles, zebrafish (Danio rerio) were exposed to the test substance under static conditions at the following nominal concentrations: 0 (blank-control), 62.5, 125, 250, 500 and 1000 mg/L. Since the test substance was insoluble, WAFs were prepared individually for each concentration. The WAFs were stirred for 7 days and subsequently filtered (0.45 µm). No analysis was conducted to determine actual exposure concentrations.
For each concentration and control group, 7 carps were exposed to the test substance during the test period in all-glass aquaria with a transparent cover. During the test period, test conditions remained stable.
No mortality was observed at any of the tested concentrations. Therefore, the 96h-LC50 was determined to be above the maximum solubility of the test substance in test media. The test substance is concluded not to be acute toxic to fish at its maximum solubility in test media. However, since no analysis was conducted and the test item is known to be insoluble in water, the actual exposure concentrations are unknown.
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