Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-374-5 | CAS number: 1569-02-4
LD0 (oral) > 1792 mg/kg (>2mls/kg)
LC0 (inhalation, 4 hrs) > 9.59 mg/L (represents approximately 22% of saturated vapour pressure.)
(analogue) methoxypropanol LD50 (dermal) >2000mg/kg
The acute toxicity of ethoxypropyl acetate is very low. The rat oral LDLo value is greater than 2.0 ml/kg (1792 mg/kg), and the rat inhalation LC0 value is greater than 9,590 mg/m3 (4-hour, nose only, vapour). No data is available for the dermal route on the substance itself, but based on an early acute dermal toxicity study in rabbits, the single dose LD50 for methoxypropanol (a close structural analogue of ethoxypropanol) applied to the occluded skin for 24-hours is greater than 2000mg/kg. A conclusion of low toxicity by the dermal route is also supported by a guideline and GLP acute dermal toxicity limit study on another close structural analogue ethoxypropoxy propanol , which did not cause any mortality at a dose of 2009mg/kg bw.
An extensive justification for read across is contained in the read across justification attached to chapter 13 of this dossier.
Available data shows that the substance ethoxypropanol has low acute toxicity by all routes of intake and therefore does not justify classification for acute toxicity. However, there is evidence to show that narcosis can occur following exposure to high concentrations and therefore use of the risk phrase R67 under directive 67/548 and classification STOT (SE) H336 is appropriate under the CLP regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again