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EC number: 216-374-5 | CAS number: 1569-02-4
Results for urinanalysis by dose group:
Urine volume (ml)
Macroscopic incidence of pale foci
Male Organ weights – (absolute – relative not significant)
Female Organ weights – (absolute – relative not significant)
Microscopic incidence of minimal focal macrophage aggregation
In a guideline and GLP 90-day whole-body inhalation study in rats, exposure to ethyoxypropanol vapour at a concentration of 8.36 mg/l for 6 hours per day, 5 days per week, for 13 weeks resulted in clinical signs indicative of irritant properties, and reduced ‘startle response’ during exposure. Increases in liver weight were also noted in female rats exposed at the 8.36 mg/l exposure level. Animals exposed at concentrations of 1.266 or 0.426 mg/l did not exhibit any evidence of adverse effects (clinical signs, body weight, food and water consumption, opthalmoscopy, haematology, blood chemistry, urinalysis, organ weights, gross or microscopic pathology). On the basis of these findings 1.266 mg/l is considered to be a subchronic NOAEC for ethoxypropanol vapour under the conditions of this study.
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