Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-374-5 | CAS number: 1569-02-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-ethoxypropan-2-ol
- EC Number:
- 216-374-5
- EC Name:
- 1-ethoxypropan-2-ol
- Cas Number:
- 1569-02-4
- Molecular formula:
- C5H12O2
- IUPAC Name:
- 1-ethoxypropan-2-ol
- Details on test material:
- - Name of test material (as cited in study report): Ethoxypropanol
- Molecular formula (if other than submission substance):
- Physical state: Liquid
- Analytical purity: 91.1%
- Impurities (identity and concentrations):
8.0% 2-ethoxy-1-propanol
0.7% 1-methoxy-2-propanol
0.1% 2-methoxy-1-propanol
0.04% 1-(2-propenyloxy)-2-propanol
- Purity test date: 6 June 1983
- Lot/batch No.: Batch No. 96 from BP Chemie, Lavera
- Storage condition of test material: At room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Each animal was uniquely identified by ear notching.
TEST ANIMALS
- Source: Charles River UK Ltd, Kent, England
- Age at study initiation: Approximately 6 weeks when received
- Weight at study initiation: Males: 210 – 235 g, Females: 165 – 180 g
- Housing: Animals were housed in groups of three or less in polypropylene cages with stainless steel grid tops and floors.
- Diet: Ad libitum access to No. 1 pelleted expanded maintenance diet from Special Diet Services Ltd, Essex, England.
- Water: Ad libitum access to water supplied by the North Surrey Water Company
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: Targeted values were 20 + 1 degree C.
- Humidity: Targeted values were 55 + 15 % relative humidity.
- Air changes: Approximately 15 changes per hour.
- Photoperiod: 14-hour light: 10-hour dark cycle.
IN-LIFE DATES: From: June 2, 1984 To: June 21, 1984
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 2 ml/kg in the main study
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: Pilot study - Doses:
- 2 ml/kg in main study.
- No. of animals per sex per dose:
- Pilot study – 1 male and 1 female
Main study – 5 males and 5 females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration:
Pilot study – 24 hours
Main study – 14 days
- Frequency of observations and weighing: Animals were observed at approximately 5, 30, 60 and 180 minutes after dosing, and at least twice daily on subsequent days. Individual body weights were recorded on Days 0, 2, 7 and 14 of the main study.
- Necropsy of survivors performed: yes
- Other examinations performed: Clinical signs were recorded at each observation interval. Each animal was subject to a detailed macroscopic examination including opening the abdominal, thoracic, and cranial cavities. The appearance of all organs was noted in situ and all abnormalities recorded; the cut surfaces of the liver and kidneys were examined. - Statistics:
- no data
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 mL/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 mL/kg bw
- Mortality:
- There were no mortalities.
- Clinical signs:
- other: Transitory slight piloerection was seen in all animals on Days 1, 7 and 13. Slight staining of the fur of the head and ears was noted in two female rats on the day of autopsy.
- Gross pathology:
- Postmortem findings were considered unrelated to treatment.
- Other findings:
- no other findings reported
Any other information on results incl. tables
All animals survived the 24-hour pilot study at doses of 2 ml/kg or 5 ml/kg. Transitory salivation, inactivity, unsteady gait, rapid respiration, staining of the fur in the urinogenital region, partial ptosis, hunched posture and prostration were seen in animals treated with ethoxypropanol at 5 ml/kg.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute lethal oral dose to rats of ethoxypropanol was greater than 2.0 ml/kg bodyweight.
- Executive summary:
In a GLP acute oral toxicity study in rats, a single dose of ethoxypropanol administered by gavage at a dose of 2.0 ml/kg (1792 mg/kg) did not produce lethality. Apart from transitory reduction in the bodyweight gain of female rats, there were no clear signs of toxicity seen at this dose level.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
