Registration Dossier
Registration Dossier
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EC number: 202-044-8 | CAS number: 91-15-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
ortho-Phthalodinitrile dissolved in dimethylformamide was assessed for its skin sensitizing potential using the Local Lymph Node Assay (LLNA) in mice according to OECD TG No.429. Concentration for the mainexperiment were chosen based on mortality and systemic toxicity in a pre experiment. Stimulation Indices (S.I.) of 1.29, 1.36, and 1.18 were determined with the test item at concentrations of 0.5, 1, and 2.5% (w/v) in dimethylformamide, respectively. A statistically significant difference in DPM/animal was not observed in any of the groups treated with different concentrations of the test item in comparison to the vehicle control group.The EC3 value could not be calculated, since none of the tested concentrations induced an S.I. greater than 3.The S.I. of the valid positive control group was 7.48. Ortho-Phthalodinitrile did not show skin sensitizing potential in this study.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Migrated from Short description of key information:
As ortho-Phthalodinitrile did not show any skin sensitizing potential in a LLNA according to OECD 429 it is not supposed to be a respiratory sensitizer.
Justification for classification or non-classification
No classification suggested for sensitization as criteria of regulation 1272/2008/EC are not met.
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