Registration Dossier
Registration Dossier
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EC number: 202-044-8 | CAS number: 91-15-6
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Chromosomenuntersuchungen bei Mitarbeitern mit Exposition • gegenüber ortho-Phthalodinitril (o-PDN)
- Author:
- Fleig I. and A.M. Thiess
- Year:
- 1 979
- Bibliographic source:
- Zbl. Arbeitsmed. 5, 127-129
Materials and methods
- Principles of method if other than guideline:
- Method: other: human Lymphocytes
- GLP compliance:
- not specified
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- Phthalonitrile
- EC Number:
- 202-044-8
- EC Name:
- Phthalonitrile
- Cas Number:
- 91-15-6
- Molecular formula:
- C8H4N2
- IUPAC Name:
- benzene-1,2-dicarbonitrile
Constituent 1
Test animals
- Species:
- other: human
Administration / exposure
- Route of administration:
- other: contamination (dermal exposure, inhalation)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
no data
Basis:
Results and discussion
Any other information on results incl. tables
RS-Freetext:
Negative, no increase of chromosomal aberration.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
