Reaction mass of geranyl acetate and neryl acetate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable study report which meets basic scientific principles

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1972

Report date:

1972

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Acute dermal toxicity study

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Neryl acetate

EC Number:

205-459-2

EC Name:

Neryl acetate

Cas Number:

141-12-8

Molecular formula:

C12H20O2

IUPAC Name:

3,7-dimethylocta-2,6-dien-1-yl acetate (Z)-

Details on test material:

- Name of test material (as cited in study report): Neryl acetate
- Lot/batch No.: 71-10-56, 1-13-72
- Physical state: clear liquid
no further data given

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 2-3 kg
- Acclimation period: min. 14 days

Administration / exposure

Type of coverage:

occlusive

Vehicle:

not specified

Details on dermal exposure:

TEST SITE
- Area of exposure: back of animal
- Type of wrap if used: covered with a snuggly fitting rubber sleeve or dam
- Test substance applied to clipped intact and abraded skin areas

REMOVAL OF TEST SUBSTANCE
- Washing (if done): no (thorougly wiped down)
- Time after start of exposure: 24 hours

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2/3.9/6 ml/kg bw
- Constant volume or concentration used: no

Duration of exposure:

24 h

Doses:

2, 3.9, 6 ml/kg bw (= 1820, 3549, 5460 mg/kg bw, based on a density of 0.91)

No. of animals per sex per dose:

4 animals/dose

Control animals:

other: not applicable

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: appropriate tissues examined histopathologically in dead animals (no further data)
- Other examinations performed:
Food consumption,
Body weights,
General behavior;
Hematology (performed during acclimatization period and 14d post dose: red/white cell count, differential, grams hemoglobin, % hematocrit) Urinalysis (performed during acclimatization period and 14d post dose)

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 6 mL/kg bw

Remarks on result:

other: corresponds to 5460 mg/kg bw, based on a density of 0.91

Mortality:

0/12

Clinical signs:

other: no effects

Gross pathology:

no data

Other findings:

Hematology: no effects
Urinalysis: no data given

Any other information on results incl. tables

No erythema, edema observed. Animals consumed their daily ration, gained weight and behaved as normal laboratory acclimated animals. No significant changes in hematogram obseverved.