2-piperazin-1-ylethanol

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1968

Report date:

1968

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Standardised study to determine the acute toxicity of the test item in mice after single i.p. application.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-piperazin-1-ylethanol

EC Number:

203-142-3

EC Name:

2-piperazin-1-ylethanol

Cas Number:

103-76-4

Molecular formula:

C6H14N2O

IUPAC Name:

2-piperazin-1-ylethanol

Test material form:

liquid

Test animals

Species:

mouse

Strain:

other: Kisslegg

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 15-34 g

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

water

Doses:

200, 400, 640, 800 cm³/kg bw (212, 424, 678, 848 mg/kg bw - conversation in mg/kg is based on the density: d= 1.06 g/cm³)
The doses were administered as aqueous solutions of 8% (800, 640 cm³/kg), 4% (400 cm³/kg) and 2% (200 cm³/kg) test substance.

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations: daily
- Frequency of weighing: before the start of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

< 678 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Corresponds to 640 cm³/kg bw; the mg/kg was calculated on the density d: d= 1.061 g/cm³. 678 mg/kg bw : all female and 2 male animals died within 48 hours post application; 424 mg/kg bw: one male and one female animal died within 7 days post application.

Mortality:

848 mg/kg bw : all animals died within 48 hours post application
678 mg/kg bw : all female and 2 male animals died within 48 hours post application
424 mg/kg bw: one male and one female animal died within 7 days post application

Clinical signs:

Immediately after application, labored respiration, aqueous secretion from the oral cavity, shrunken flanks, high stepping gait, indicated morphine tails, abdominal position and closed eyes were observed. During the following days, the surviving animals showed clotted eyes, scrubby fur, accelerated respiration. 5 to 6 days after exposure, no clinical signs were observed.

Body weight:

no data

Gross pathology:

Animals that died: clear odor of test substance, livers with bloody pigmentation, intestine filled with bloody fluids
Animals examined at termination of the study: connation of liver and stomach