Registration Dossier
Registration Dossier
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EC number: 203-142-3 | CAS number: 103-76-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 6 410 mg/L
Additional information
The toxic effect of 2 -piperazin-1-ylethanol (CAS 103-76-4) was studied with Pimephales promelas as test species under flow-through conditions performed similar to OECD 203 (Geiger et al., 1986). The test item concentrations were analytically verified. The 96-h LC50 was determined to be 6410 mg/L using pH-adjusted test solutions.
In another study according to German Industrial Standard DIN 38412, part 15, the toxic effect to the test species Leuciscus idus was studies under static exposure conditions. The test species was Leuciscus idus. The test item concentrations were not analyticaly verified. The 96 -h LC50 was determined to be 681 mg/L based on not pH-adjusted test solutions (geometric mean of LC0 and LC100; pH 7.7 to 10.9). A pH-adjusted test sample of 4640 mg/L caused no mortality (pH 7.2 to 8.0; BASF AG, 1988; report no. 10F0724/875016).
In a third study performed according to OECD 203, the test species was Oncorhynchus mykiss which was exposed under semi-static conditions with daily exchange of the test solutions. The pH of the test solutions was not adjusted and thus ranging from pH 8.7 to 9.9. The test item concentrations were not analytically verified. The 96-h LC50 was determined to be 750 mg/L.
The study by Geiger et al. (1986) was selected as key study, since the test concentrations were analytically verified and the test solutions were pH-adjusted. The data from the not pH-adjusted test solutions gave LC50 values of about the same level. These results are regarded as supporting studies and represent the effect level without pH-adjustment.
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