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Physical & Chemical properties

Vapour pressure

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Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 18 March 2008 to 12 May 2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. The substance is considered to be adequately characterised. Therefore full validation applies.
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
UK GLP Monitoring Authority (inspected on August 21, 2007/ signed on October 15, 2007
Type of method:
effusion method: vapour pressure balance
Temp.:
25 °C
Vapour pressure:
1.5 Pa

Detailed results and graphes of Log10 (vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) are available in the test report.

Summary of results:

 Run  Log10 [VP(25°C)]
 1  0.170
 2  0.172
 3  0.172
 4  0.175
 5  0.167
 6  0.167
 7  0.172
 mean  0.171
 Vapour Pressure  1.483 Pa
Conclusions:
Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), < 500 Pa).
Executive summary:

The vapour pressure was determined under GLP according to EU A4 guideline, vapour pressure balance method. Seven runs were performed with 8 to 10 measurements being made between 8 and 17°C, then linear regression analysis was used to calculate the vapour pressure at 25°C from each run, and the mean value was retained.

The extrapolated vapour pressure of the test material has been determined to be 1.5 Pa (0.015 hPa) at 25°C.

Endpoint:
vapour pressure
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Based on structural similarity (same isomers in a different ratio) and on compared boiling points, respectively 270°C (under 102.93 kPa) for the test substance (Safepharm 2008c), and 269°C (under 99.5 kPa) for the present dossier (Safepharm 2008a; please refer to IU section 4.3), both substances are not expected to have significantly different vapour pressure. Therefore, the result of the study will be considered for the dossier substance.
Further information is included in IUCLID Section 13.
Reason / purpose:
read-across source
Reason / purpose:
read-across: supporting information
Reason / purpose:
read-across: supporting information
Key result
Temp.:
25 °C
Vapour pressure:
ca. 1.5 Pa
Conclusions:
(from analogue) Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), < 500 Pa).
Executive summary:

The vapour pressure of the analogue was determined under GLP according to EU A4 guideline, vapour pressure balance method. Seven runs were performed with 8 to 10 measurements being made between 8 and 17°C, then linear regression analysis was used to calculate the vapour pressure at 25°C from each run, and the mean value was retained.

The extrapolated vapour pressure of the test material has been determined to be 1.5 Pa (0.015 hPa) at 25°C.

Description of key information

Low volatility (from analogue).

Key value for chemical safety assessment

Vapour pressure:
1.5 Pa
at the temperature of:
25 °C

Additional information

No data is available on the substance itself. However, a fully reliable experimental study, conducted according to a recognized EC method and under GLP, is available on an analogue (same isomers in a different ratio). Based on compared boiling points, no significant difference is anticipated with the present dossier substance, the read-across is considered justified for a key study, and the result is retained as key data for purpose of CSA.