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Physical & Chemical properties

Surface tension

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Endpoint:
surface tension
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 31 January 2008 to 04 June 2008
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. It is considered reliable with restrictions due to measured concentration.
Qualifier:
according to
Guideline:
OECD Guideline 115 (Surface Tension of Aqueous Solutions)
Deviations:
yes
Remarks:
See "Any other information on material and methods incl. tables"
Qualifier:
according to
Guideline:
EU Method A.5 (Surface Tension)
Deviations:
yes
Remarks:
See "Any other information on material and methods incl. tables"
GLP compliance:
yes (incl. certificate)
Remarks:
UK GLP Monitoring Authority (inspected on August 21, 2007/ signed on October 15, 2007
Type of method:
ring method
Surface tension:
58.7 mN/m
Temp.:
21 °C
Conc.:
0.011 g/L

Substances having a surface tension below 60 mN/m are regarded as being surface-active by Method A5. However, a classic surfactant will have a value of approximately 40 mN/m or less. This test material gave a value of 58.7 rnN/m. Although this is designated surface-active by Method A5 it was considered that this value was not low enough to solely designate the material surface-active, especially since the test material does not have a typical surfactant structure (polar head with carbon chain).

Therefore, to provide further information, an assessment of the emulsification properties of the test material was carried out with the test material prepared in water saturated n-octanol and partitioned with an equal amount of n-octanol saturated water. Observations after this test showed that the two immiscible phases separated fully and no emulsification was observed.

Conclusions:
According to EU A5 criteria, as the result is below the threshold value of 60 mN/m, the substance is considered to have surface-active potential under the experimental conditions.
Executive summary:

The determination of surface tension was carried out using a White Electrical Institute interfacial tension balance and a procedure based on the ISO 304 ring method, under GLP. Minor deviation has been considered not to have affected the integrity of the study.

The surface tension of a 0.112 g/L of test material has been determined to be 58.7 mN/m at 21.0°C.

Endpoint:
surface tension
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Based on structural similarity (same isomers in a different ratio) and comparing water solubility, respectively 13.5 mg/L for the test substance (Safepharm 2008c), and 10.3 mg/L for the present dossier (Safepharm 2008a; please refer to IU section 4.8), both substances are not expected to have significantly different surface tension. Therefore the result of the study will be considered for the dossier substance.
Further information is included in IUCLID Section 13.
Reason / purpose:
read-across source
Reason / purpose:
read-across: supporting information
Reason / purpose:
read-across: supporting information
Surface tension:
ca. 58.7 mN/m
Temp.:
21 °C
Conc.:
90 other: % saturation
Conclusions:
According to EU A5 criteria, based on analogue data, the result for this dossier substance is anticipated to fall below the threshold value of 60 mN/m. Therefore, the substance is considered to have weak surface-active potential under the experimental conditions.
Executive summary:

The determination of surface tension of the analogue was carried out using a White Electrical Institute interfacial tension balance and a procedure based on the ISO 304 ring method, under GLP.

The surface tension of a 0.112 g/L of test material has been determined to be 58.7 mN/m at 21.0°C.

Description of key information

According to EU A5 criteria, based on analogue data, the result for this dossier substance is anticipated to fall below the threshold value of 60 mN/m. Therefore, the substance is considered to have surface-active potential under the experimental conditions.

However, since the structure is not characteristic of a true surfactant, and it is not the intended use of the substance (i.e. not a desired property), this conclusion should be taken with caution.

Key value for chemical safety assessment

Additional information

No data is available on the substance itself. However, a reliable experimental study, conducted according to a recognized OECD/EU/ISO method and under GLP, is available on an analogue. Based on chemical similarity (same isomers in a different ratio), and comparing also water solubility, the conclusion of the study is considered suitable for purpose of qualitative assessment on the present substance, and the read-across is considered justified for a key study, but the result will not be retained as key value.