Mandelic acid

Endpoint summary

Description of key information

Compilation of available data was provided in a WoE approach.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1938-1946

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Studies reported in scientific journals using different species and routes of administration.

Qualifier:

no guideline followed

Principles of method if other than guideline:

For details see text below

GLP compliance:

no

Test type:

other: For details see text below

Limit test:

no

Specific details on test material used for the study:

no data

Species:

other: Rabbit, Rat, Guinea Pig

Details on test animals or test system and environmental conditions:

na data

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

For details see text below

No. of animals per sex per dose:

For details see text below

Control animals:

not specified

Details on study design:

For details see text below

Key result

Sex:

not specified

Dose descriptor:

LD50

Remarks:

based on studies in rats (Ormond, 1938; Meier 1940)

Effect level:

> 2 000 mg/kg bw

Based on:

not specified

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

2 000 mg/kg bw