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Administrative data

Description of key information

Compilation of available data was provided in a WoE approach.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1938-1946
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Studies reported in scientific journals using different species and routes of administration.
Qualifier:
no guideline followed
Principles of method if other than guideline:
For details see text below
GLP compliance:
no
Test type:
other: For details see text below
Limit test:
no
Specific details on test material used for the study:
no data
Species:
other: Rabbit, Rat, Guinea Pig
Details on test animals or test system and environmental conditions:
na data
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
For details see text below
No. of animals per sex per dose:
For details see text below
Control animals:
not specified
Details on study design:
For details see text below
Key result
Sex:
not specified
Dose descriptor:
LD50
Remarks:
based on studies in rats (Ormond, 1938; Meier 1940)
Effect level:
> 2 000 mg/kg bw
Based on:
not specified
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Justification for classification or non-classification