Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 202-007-6 | CAS number: 90-64-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1938-1946
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Studies reported in scientific journals using different species and routes of administration.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Beitrag zur Toxikologie der Mandelsäure
- Author:
- Meier K
- Year:
- 1 940
- Bibliographic source:
- Arch Intern. Pharmacodyn. 1940, XLIV, fasc. 1.
- Report date:
- 1939
- Reference Type:
- review article or handbook
- Title:
- no data
- Author:
- Ormond JK
- Year:
- 1 938
- Bibliographic source:
- J Urol. (1938), 39, 714
- Report date:
- 1938
- Reference Type:
- publication
- Title:
- Inhibition of the appearance of gastric ulcers in rats, using benzoic derivatives
- Author:
- Carminati GM, Chiabotto L, Duzzi L.
- Year:
- 1 973
- Bibliographic source:
- 1. Carminati GM, Chiabotto L, Duzzi L. [Inhibition of the appearance of gastric ulcers in rats, using benzoic derivatives]. Boll Chim Farm. 1973 Jan;112(1):53–63.
- Report date:
- 1973
- Reference Type:
- secondary source
- Title:
- Experimental Medicine and Surgery
- Author:
- Boyd EM, Seymour KG
- Year:
- 1 946
- Bibliographic source:
- Experimental Medicine and Surgery. Vol. 4, Pg. 223, 1946.
- Report date:
- 1946
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- For details see text below
- GLP compliance:
- no
- Test type:
- other: For details see text below
- Limit test:
- no
Test material
- Reference substance name:
- Mandelic acid
- EC Number:
- 202-007-6
- EC Name:
- Mandelic acid
- Cas Number:
- 90-64-2
- Molecular formula:
- C8H8O3
- IUPAC Name:
- hydroxy(phenyl)acetic acid
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- no data
Test animals
- Species:
- other: Rabbit, Rat, Guinea Pig
- Details on test animals or test system and environmental conditions:
- na data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- For details see text below
- No. of animals per sex per dose:
- For details see text below
- Control animals:
- not specified
- Details on study design:
- For details see text below
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- based on studies in rats (Ormond, 1938; Meier 1940)
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
