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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1938-1946
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Studies reported in scientific journals using different species and routes of administration.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Beitrag zur Toxikologie der Mandelsäure
Author:
Meier K
Year:
1940
Bibliographic source:
Arch Intern. Pharmacodyn. 1940, XLIV, fasc. 1.
Report date:
1939
Reference Type:
review article or handbook
Title:
no data
Author:
Ormond JK
Year:
1938
Bibliographic source:
J Urol. (1938), 39, 714
Report date:
1938
Reference Type:
publication
Title:
Inhibition of the appearance of gastric ulcers in rats, using benzoic derivatives
Author:
Carminati GM, Chiabotto L, Duzzi L.
Year:
1973
Bibliographic source:
1. Carminati GM, Chiabotto L, Duzzi L. [Inhibition of the appearance of gastric ulcers in rats, using benzoic derivatives]. Boll Chim Farm. 1973 Jan;112(1):53–63.
Report date:
1973
Reference Type:
secondary source
Title:
Experimental Medicine and Surgery
Author:
Boyd EM, Seymour KG
Year:
1946
Bibliographic source:
Experimental Medicine and Surgery. Vol. 4, Pg. 223, 1946.
Report date:
1946

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
For details see text below
GLP compliance:
no
Test type:
other: For details see text below
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Mandelic acid
EC Number:
202-007-6
EC Name:
Mandelic acid
Cas Number:
90-64-2
Molecular formula:
C8H8O3
IUPAC Name:
2-hydroxy-2-phenylacetic acid
Test material form:
solid
Specific details on test material used for the study:
no data

Test animals

Species:
other: Rabbit, Rat, Guinea Pig
Details on test animals or test system and environmental conditions:
na data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
For details see text below
No. of animals per sex per dose:
For details see text below
Control animals:
not specified
Details on study design:
For details see text below

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Remarks:
based on studies in rats (Ormond, 1938; Meier 1940)
Effect level:
> 2 000 mg/kg bw
Based on:
not specified

Applicant's summary and conclusion