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Diss Factsheets
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EC number: 811-432-1 | CAS number: 78433-08-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: Expert review and assessment of available data.
- Adequacy of study:
- key study
- Study period:
- Report Issued: 13 February 2019.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Not assignable as the result is from expert assessment.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2019
Materials and methods
- Objective of study:
- other: Basic toxicokinetic assessment to support REACH Annex VIII registration.
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Expert review of available data at REACH Annex VIII tonnage level.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-[(octadecylcarbamoyl)oxy]ethyl acrylate
- EC Number:
- 811-432-1
- Cas Number:
- 78433-08-6
- Molecular formula:
- C24H45NO4
- IUPAC Name:
- 2-[(octadecylcarbamoyl)oxy]ethyl acrylate
- Test material form:
- solid
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- It is not possible to draw conclusions about the toxicokinetic profile of Propenoic acid, 2-[[(octadecylamino)carbonyl]oxy]ethyl ester from either acute and repeated dose oral toxicity studies or ecotoxicity studies as apart from some body weight effects in an acute inhalation study, no effects of note were observed following treatment. As a result it is not possible to determine if either the substance is systemically absorbed, or absorbed but to such a low degree that it cannot exert toxicity, or it is of such low toxicity that it is unable to exert any adverse effects.
Based on its physicochemical profile it is expected that the substance will be soluble in lipids and fats and if it is absorbed it could partition into body fats; however, given its chemical composition it is likely it will undergo metabolism and hence it is unlikely to accumulate in the body. - Executive summary:
Introduction
An expert review of toxicokinetic data on Propenoic acid, 2-[[(octadecylamino)carbonyl]oxy]ethyl ester was undertaken to provide a basic toxicokinetic asessment as required for REACH Annex VIII registration. The assessment was based on available data from toxicological studies studies. No specific toxicokinetic studies were undertaken.
Conclusion
It is not possible to draw conclusions about the toxicokinetic profile of Propenoic acid, 2-[[(octadecylamino)carbonyl]oxy]ethyl esterfrom either acute and repeated dose oral toxicity studies or ecotoxicity studiesas apart from some body weight effects in an acute inhalation study, no effects of note were observed following treatment. As a result it is not possible to determine if either the substance is systemically absorbed, or absorbed but to such a low degree that it cannot exert toxicity, or it is of such low toxicity that it is unable to exert any adverse effects.
Based on its physicochemical profile it is expected that the substance will be soluble in lipids and fats and if it is absorbed it could partition into body fats; however, given its chemical composition it is likely it will undergo metabolism and hence it is unlikely to accumulate in the body.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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