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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Appearance/Physical state: White solid
Purity: >98%
Expiry date: 20 June 2017
Storage conditions: Room temperature in the dark
Analytical method:
high-performance liquid chromatography
Key result
Type:
Pow
Partition coefficient:
> 3 160 000
Temp.:
30 °C
pH:
7
Remarks on result:
other:
Remarks:
Column temperature
Key result
Type:
log Pow
Partition coefficient:
> 6.5
Temp.:
30 °C
pH:
7
Remarks on result:
other:
Remarks:
Column temperature
Details on results:
The result from the preliminary test indicated that the HPLC method was suitable for determination of partition coefficient for this test item.
Conclusions:
The partition coefficient of the test item has been determined to be greater than 3.16 x 106, log10 Pow greater than 6.5.

Description of key information

In an OECD 117 study, under GLP conditions, the partition coefficient (Pow) of 2-Propenoic acid, 2‑[[(octadecylamino)carbonyl]oxy]ethyl ester is greater than 3.16 x 106, log10 Pow greater than 6.5 Envigo, 2016a).

Key value for chemical safety assessment

Log Kow (Log Pow):
6.5
at the temperature of:
30 °C

Additional information