4-nitro-o-toluidine

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

data is from experimental reports

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Principles of method if other than guideline:

The water solubility determination of test item 4-nitro-o-toluidine (CAS No. 99-52-5) was done as per the OECD guideline 105 and by spectrophotometric analytical method as per OECD 101.

GLP compliance:

not specified

Type of method:

flask method

Specific details on test material used for the study:

- Name of test material (as cited in study report): 2-methyl-4-nitroaniline
- Molecular formula: C7H8N2O2
- Molecular weight: 152.152 g/mol
- Smiles notation: c1(cc(c(N)cc1)C)[N+](=O)[O-]
- InChI: 1S/C7H8N2O2/c1-5-4-6(9(10)11)2-3-7(5)8/h2-4H,8H2,1H3
- Substance type: Organic
- Physical state: Solid

Key result

Water solubility:

202.17 mg/L

Conc. based on:

test mat.

Temp.:

30 °C

Remarks on result:

other: no additional details mentioned

Sample stirring time (hours)	Concentration obtained on the basis of standard curve (mg/l)	Dilution factor	Solubility value obtained (mg/l)
24	-	-	-
48	10.1773	20	203.546
72	10.0397	20	200.794

Considering the water solubility for 48 hrs and 72 hrs the mean water solubility was calculated as follows:

Mean water solubility value for 48 hour run sample + 72 hour run sample

=(203.546+200.794)/2

=202.17 mg/L

Conclusions:

The water solubility determination of test item 4-nitro-o-toluidine [CAS No.99-52-5] was doneby spectrophotometric method. The water solubility was determined to be 202.17 mg/L at 30°C.

Executive summary:

The water solubility determination of test item 4-nitro-o-toluidine (CAS No. 99-52-5) was done as per the OECD guideline 105 and by spectrophotometric analytical method as per OECD 101. The solubility of 4-nitro-o-toluidine (CAS:99-52-5 ) in water was determined to be 202.17 mg/L at 30°C.

Description of key information

The water solubility determination of test item 4-nitro-o-toluidine (CAS No. 99-52-5) was done as per the OECD guideline 105 and by spectrophotometric analytical method as per OECD 101. The solubility of 4-nitro-o-toluidine (CAS:99-52-5 ) in water was determined to be 202.17 mg/L at 30°C.

Key value for chemical safety assessment

Water solubility:

202.17 mg/L

at the temperature of:

30 °C

Additional information

The water solubility determination of test item 4-nitro-o-toluidine (CAS No. 99-52-5) was done as per the OECD guideline 105 and by spectrophotometric analytical method as per OECD 101. The solubility of 4-nitro-o-toluidine (CAS:99-52-5 ) in water was determined to be 202.17 mg/L at 30°C.

Data from authoritative database suggests that the experimental water solubility of 2-methyl-4-nitroaniline at 20°C was 140 mg/L.

These values indicate that 2-methyl-4-nitroaniline is moderately soluble in water.