4-nitro-o-toluidine

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

4 (not assignable)

Qualifier:

according to guideline

Guideline:

other: refer below principle

Principles of method if other than guideline:

QSTR Study on Aquatic Toxicity Against Tetrahymena pyriformis Using Topological Indices.

GLP compliance:

no

Specific details on test material used for the study:

- IUPAC name 2-methyl-4-nitroaniline
- Name of test material: 4-nitro-o-toluidine
- Molecular formula: C7H8N2O2
- Molecular weight: 152.152 g/mol
- Physical state: Solid
- SMILES: c1(cc(c(N)cc1)C)[N+](=O)[O-]
- InChI: 1S/C7H8N2O2/c1-5-4-6(9(10)11)2-3-7(5)8/h2-4H,8H2,1H3

Analytical monitoring:

no

Vehicle:

not specified

Test organisms (species):

Tetrahymena pyriformis

Test type:

not specified

Water media type:

freshwater

Remarks on exposure duration:

not specified in study

Reference substance (positive control):

not specified

Key result

Dose descriptor:

other: IGC50

Effect conc.:

109.64 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Remarks on result:

other: 1/log IGC50 =2.04 which is equivalent to 109.64 mg/l

Reported statistics and error estimates:

TOPOCLUJ software program

Validity criteria fulfilled:

not specified

Conclusions:

QSTR Study on Aquatic Toxicity Against Tetrahymena pyriformis using Topological Indices for chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) indicate that the toxicity data as 50% growth inhibitory concentration (log 1/IGC50 = pIGC50) against micro organism species Tetrahymena pyriformis was estimate to be 1/log IGC50 =2.04 which is equivalent to 109.64 mg/l.

Executive summary:

QSTR Study on Aquatic Toxicity Against Tetrahymena pyriformis using Topological Indices for chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) indicate that the toxicity data as 50% growth inhibitory concentration (log 1/IGC50 = pIGC50) against micro organism species Tetrahymena pyriformis was estimate to be 1/log IGC50 =2.04 which is equivalent to 109.64 mg/l.This estimated IGC50 value suggest that chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) may not have toxicity concern to micro organism Tetrahymena pyriformis.

Description of key information

QSTR Study on Aquatic Toxicity Against Tetrahymena pyriformis using Topological Indices for chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) indicate that the toxicity data as 50% growth inhibitory concentration (log 1/IGC50 = pIGC50) against micro organism species Tetrahymena pyriformis was estimate to be 1/log IGC50 =2.04 which is equivalent to 109.64 mg/l.

Key value for chemical safety assessment

EC50 for microorganisms:

109.64 mg/L

Additional information

QSTR Study on Aquatic Toxicity Against Tetrahymena pyriformis using Topological Indices for chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) indicate that the toxicity data as 50% growth inhibitory concentration (log 1/IGC50 = pIGC50) against micro organism species Tetrahymena pyriformis was estimate to be 1/log IGC50 =2.04 which is equivalent to 109.64 mg/l.This estimated IGC50 value suggest that chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) may not have toxicity concern to micro organism Tetrahymena pyriformis.