Registration Dossier

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Qualifier:
according to
Guideline:
other: refer below principle
Principles of method if other than guideline:
QSTR Study on Aquatic Toxicity Against Tetrahymena pyriformis Using Topological Indices.
GLP compliance:
no
Specific details on test material used for the study:
- IUPAC name 2-methyl-4-nitroaniline
- Name of test material: 4-nitro-o-toluidine
- Molecular formula: C7H8N2O2
- Molecular weight: 152.152 g/mol
- Physical state: Solid
- SMILES: c1(cc(c(N)cc1)C)[N+](=O)[O-]
- InChI: 1S/C7H8N2O2/c1-5-4-6(9(10)11)2-3-7(5)8/h2-4H,8H2,1H3
Analytical monitoring:
no
Vehicle:
not specified
Test organisms (species):
Tetrahymena pyriformis
Test type:
not specified
Water media type:
freshwater
Remarks on exposure duration:
not specified in study
Reference substance (positive control):
not specified
Key result
Dose descriptor:
other: IGC50
Effect conc.:
109.64 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: 1/log IGC50 =2.04 which is equivalent to 109.64 mg/l
Reported statistics and error estimates:
TOPOCLUJ software program
Validity criteria fulfilled:
not specified
Conclusions:
QSTR Study on Aquatic Toxicity Against Tetrahymena pyriformis using Topological Indices for chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) indicate that the toxicity data as 50% growth inhibitory concentration (log 1/IGC50 = pIGC50) against micro organism species Tetrahymena pyriformis was estimate to be 1/log IGC50 =2.04 which is equivalent to 109.64 mg/l.
Executive summary:

QSTR Study on Aquatic Toxicity Against Tetrahymena pyriformis using Topological Indices for chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) indicate that the toxicity data as 50% growth inhibitory concentration (log 1/IGC50 = pIGC50) against micro organism species Tetrahymena pyriformis was estimate to be 1/log IGC50 =2.04 which is equivalent to 109.64 mg/l.This estimated IGC50 value suggest that chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) may not have toxicity concern to micro organism Tetrahymena pyriformis.

Description of key information

QSTR Study on Aquatic Toxicity Against Tetrahymena pyriformis using Topological Indices for chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) indicate that the toxicity data as 50% growth inhibitory concentration (log 1/IGC50 = pIGC50) against micro organism species Tetrahymena pyriformis was estimate to be 1/log IGC50 =2.04 which is equivalent to 109.64 mg/l.

Key value for chemical safety assessment

EC50 for microorganisms:
109.64 mg/L

Additional information

QSTR Study on Aquatic Toxicity Against Tetrahymena pyriformis using Topological Indices for chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) indicate that the toxicity data as 50% growth inhibitory concentration (log 1/IGC50 = pIGC50) against micro organism species Tetrahymena pyriformis was estimate to be 1/log IGC50 =2.04 which is equivalent to 109.64 mg/l.This estimated IGC50 value suggest that chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) may not have toxicity concern to micro organism Tetrahymena pyriformis.