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Diss Factsheets
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EC number: 211-661-1 | CAS number: 682-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- March 1 - 6, 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant study conducted according the appropriate test guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-allyloxymethyl-2-ethylpropanediol
- EC Number:
- 211-662-7
- EC Name:
- 2-allyloxymethyl-2-ethylpropanediol
- Cas Number:
- 682-11-1
- Molecular formula:
- C9H18O3
- IUPAC Name:
- 2-[(allyloxy)methyl]-2-methylbutane-1,1-diol
- Reference substance name:
- trimethylolpropane monoallyl ether (TMPME)
- IUPAC Name:
- trimethylolpropane monoallyl ether (TMPME)
- Details on test material:
- Concentration of TMPME - 99.0%.
Lot number - 3852802
Appearance - clear, colourless liquid
Density - 1010 kg/m3
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
TMPME is being used as a surrogate for TMPDE.
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Portions of the test solution was sampled before the test and after 24 hours for analysis in the Sponsor's Laboratory. The analytical details and results have not been supplied.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- 24 hours prior to each exposure period 50 g of TMPME was dissolved in one litre of aerated dilution water and stirred for 24 hours. The water phase was used as the stock solution.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- No details have been reported. The fish species tested is not explicity stated but can be inferred from the statement that "the dilution water should allow survival of zebra fish for at least 96 hours".
Fish were placed in quarantine for 14 days prior to use in the study.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- Not applicable
Test conditions
- Hardness:
- Dilution water had a hardness in the range of 250 ± 25 mg calcium carbonate/L.
- Test temperature:
- The range over the course of the study was 23 ± 1°C
- pH:
- The range over the course of the study was 7.4 - 8.0
- Dissolved oxygen:
- The range over the course of the study was 73 - 100 % air saturation
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Nominal exposure concentrations: 0 (xcontrol), 200, 400, 800, 1600 and 3200 mg/L
- Details on test conditions:
- No details
- Reference substance (positive control):
- yes
- Remarks:
- Disodium heptachromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 400 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- behaviour
- Details on results:
- Visible abnormalities (e.g. darker pigmentation, loss of equilibrium, disturbance in swimming behavior or increased respiration) were observed in all of the fish in the 800 mg/L treatment.
- Results with reference substance (positive control):
- The 24 hour LC50 of disodium heptachromate fulfilled the acceptance cirterion of 200 - 400 mg/L (S 028162).
- Reported statistics and error estimates:
- Not reported.
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Fish mortality during the study is presented below:
Nominal exposure conc. (mg/L)
Cumulative mortality (seven fish per concentration)
% mortality at 96 hours
3 hours
24 hours
48 hours
72 hours
96 hours
Control
0
0
0
0
0
0
200
0
0
0
0
0
0
400
0
0
0
0
0
0
800
0
0
0
0
0
0
1600
6
7
7
7
7
100
3200
7
7
7
7
7
100
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Zebra fish were exposed to TMPME at nominal concentrations of 200, 400, 800, 1600 and 3200 mg/L in a semi-static 96 -hour acute toxicity test according to OECD 203 guidelines. The test design included an untreated control comprising of dilution water only. The 96-hour LC50 determined was 1200 mg TMPME/L (based nominal exposure concentrations). The NOEC (no-observed effect concentration) was 400 mg TMPME/L.
- Executive summary:
Zebra fish were exposed to TMPME at nominal concentrations of 200, 400, 800, 1600 and 3200 mg/L in a semi-static 96 -hour acute toxicity test according to OECD 203 guidelines. The test design included an untreated control comprising of dilution water only. The 96-hour LC50 determined was 1200 mg TMPME/L (based nominal exposure concentrations). The NOEC (no-observed effect concentration) was 400 mg TMPME/L.
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