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Description of key information

Pivalic acid is practically not toxic by the oral, dermal and inhalation routes of exposure in laboratory animals.  The acute rat oral LD50 was 2000 mg/kg of body weight.  The acute rat and guinea pig 4 hr inhalation LC50 was > 4 mg/L and mouse 4 hr inhalation LC100 was <= 4 mg/L .  The acute dermal LD50 was 3160 mg/kg of body weight. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
3 160 mg/kg bw

Additional information

Acute oral LD50=2000 mg/kg

Acute inhalation rat LC50>5.30 mg/l

Acute dermal LD50=3160 mg/kg

Justification for classification or non-classification