Registration Dossier

Administrative data

Description of key information

Pivalic acid is practically not toxic by the oral, dermal and inhalation routes of exposure in laboratory animals.  The acute rat oral LD50 was 2000 mg/kg of body weight.  The acute rat and guinea pig 4 hr inhalation LC50 was > 4 mg/L and mouse 4 hr inhalation LC100 was <= 4 mg/L .  The acute dermal LD50 was 3160 mg/kg of body weight. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
3 160 mg/kg bw

Additional information

Acute oral LD50=2000 mg/kg

Acute inhalation rat LC50>5.30 mg/l

Acute dermal LD50=3160 mg/kg

Justification for classification or non-classification