Registration Dossier
Registration Dossier
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EC number: 251-068-5 | CAS number: 32503-27-8
Endpoint summary
Administrative data
Description of key information
Skin Irritation:
The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5).The experimental pH of tetrabutylammonium hydrogen sulphate was 1.73.Hence this endpoint was considered for waiver.
Eye Irritation:
The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5).The experimental pH of tetrabutylammonium hydrogen sulphate was 1.73.Hence this endpoint was considered for waiver.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study need not be conducted because the substance is a strong acid (pH <= 2.0) or base (pH => 11.5)
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study need not be conducted because the substance is a strong acid (pH <= 2.0) or base (pH => 11.5)
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin and Eye Irritation:
The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5).The experimental pH of tetrabutylammonium hydrogen sulphate was 1.73.This low value for 1%w/v solution indicates the possibility of lower pH in case of pure substance.
Hence these endpoints were considered for waiver.
Justification for classification or non-classification
According to the CLP Regulation (EC n. 1272/2008) and based on the low pH of tetrabutylammonium hydrogen sulphate, 1% w/v solution (pH= 1.73), the classification H314 (Causes severe skin burns and eye damage) is proposed for tetrabutylammonium hydrogen sulphate.
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