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Biodegradation in water

Biodegradability of Tetrabutylammonium hydrogen sulphate (CAS no. 32503 -27 -8) is predicted using QSAR toolbox version 3.4with logKow as the primary descriptor(2017). Test substance undergoes 41.2% degradation by CO2 evolution parameter in 28 days Thus, based on percentage degradation, the test chemical Tetrabutylammonium hydrogen sulphate was estimated to be not readily biodegradable in nature.

Biodegradation in water and sediment

Estimation Programs Interface (EPI) Suite (2017) prediction model was run to predict the half-life in water and sediment for the test compound Tetrabutyl ammonium hydrogen sulphate (CAS No.32503 -27 -8). If released in to the environment, 17.8% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 8.666 days (208 hrs). The half-life (8.666 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of test chemical Tetrabutylammonium hydrogen sulphate in sediment is estimated to be 77.916 days (1870 hrs). Based on this half-life value (77.916 days), it indicates that the chemical Tetrabutylammonium hydrogen sulphate is not persistent in sediment.

Biodegradation in soil

The half-life period of Tetrabutylammonium hydrogen sulphate (CAS No. 32503 -27 -8) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 80% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Tetrabutylammonium hydrogen sulphate in soil is estimated to be 17.333 days (416 hrs). Based on this half-life value of Tetrabutylammonium hydrogen sulphate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

Additional information

Biodegradation in water

Various predicted data for the test compoundTetrabutylammonium hydrogen sulphate(CAS No. 32503-27-8) and the experimental reports for its read across substance were reviewed for the biodegradation end point, which are summarized as below:

 

In a predicted data done SSS (2017) by usingQSAR toolbox version 3.4 with logKow as the primary descriptor, percentage biodegradability oftest chemical Tetrabutylammonium hydrogen sulphate (CAS no. 32503 -27 -8) was estimated. Test substance undergoes 41.2% degradation by CO2 evolution parameter in 28 days Thus, based on percentage degradation, the test chemical Tetrabutylammonium hydrogen sulphate was estimated to be not readily biodegradable in nature.

In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound Tetrabutylammonium hydrogen sulphate (CAS no. 32503 -27 -8) in the presence of mixed populations of environmental microorganisms was estimated. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that Tetrabutyl ammonium hydrogen sulphate is expected to be not readily biodegradable.

 

Another weight of evidence study of biodegradation was conducted for 28 days for evaluating the percentage biodegradability of read across substance Tetrapropylammonium bromide (CAS no. 1941 -30 -6) (J-CHECK, 2016). Concentration of inoculum i.e, sludge used was 30 mg/l and initial substance conc. used in the study was 100 mg/l. The percentage degradation of read across substance was determined to be 0% by O2 consumption, BOD, TOC removal, test mat. analysis and IC parameter in 28 days. Thus, based on percentage degradation, Tetrapropyl ammonium bromide was considered to be not readily biodegradable in nature.

 

In an additional study of read across substance Didecyl dimethyl ammonium chloride (CAS no. 7173-51-5) from authoritative database (J-CHECK, 2016), biodegradation experiment was carried out for 28 days for evaluating the percentage biodegradability of read across substance Didecyl dimethyl ammonium chloride. The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I)) and other guideline "Biodegradation test of a chemical substance using a microorganism etc." provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively. Concentration of inoculum i.e, sludge used was 30 mg/l and initial substance conc. used in the study was 100 mg/l. The percentage degradation of read across substance was determined to be 0% by BOD, O2 consumption, test mat. analysis and LC-MS parameter in 28 days. Thus, based on percentage degradation, Didecyl dimethyl ammonium chloride was considered to be not readily biodegradable in nature.

 

On the basis of above results for target and read across substance, it can be concluded that the test substanceTetrabutylammonium hydrogen sulphate can be expected to be not readily biodegradable in nature.

Biodegradation in water and sediment

Estimation Programs Interface (EPI) Suite (2017) prediction model was run to predict the half-life in water and sediment for the test compound Tetrabutyl ammonium hydrogen sulphate (CAS No.32503 -27 -8). If released in to the environment, 17.8% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 8.666 days (208 hrs). The half-life (8.666 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of test chemical Tetrabutylammonium hydrogen sulphate in sediment is estimated to be 77.916 days (1870 hrs). Based on this half-life value (77.916 days), it indicates that the chemical Tetrabutylammonium hydrogen sulphate is not persistent in sediment.

Biodegradation in soil

The half-life period of Tetrabutylammonium hydrogen sulphate (CAS No. 32503 -27 -8) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 80% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Tetrabutylammonium hydrogen sulphate in soil is estimated to be 17.333 days (416 hrs). Based on this half-life value of Tetrabutylammonium hydrogen sulphate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

On the basis of available information, the test substance Tetrabutylammonium hydrogen sulphate can be considered to be not readily biodegradable in nature.