Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-497-0 | CAS number: -
No tables included based on negative results.
In an acute dermal toxicity study, groups of New Zealand White rabbits (4 male, 4 female) were dermally exposed to undiluted Neodene 6 at a dose of 2000 mg/kg bw. Each animal was treated at two application sites; one intact and one abraded. Controls (4 male, 4 female) were treated with deionised water. The treated skin was covered with surgical gauze and held in place with non-irritating adhesive tape, then covered with aluminium foil and an elastic bandage. The exposed area was gently washed after 24 hours of exposure and animals were observed at 1, 2, 4, 6, and 24 hours and twice daily for 14 days. Each exposure site was scored for degree of irritation according to the method of Draize following the removal of the occlusive covering until study termination. Body weights were determined on days -1, 0, 7, and 14. Survivors were necropsied on day 14.
All animals survived until end of study. There were no clinical signs of toxicity or effects on body weight. The skin was the only area affected with minimal irritation noted after the 24 -hour exposure period. By day 14, there was no evidence of irritation; however, at necropsy white crusty material on skin and fur, alopecia, and abrasions and focal reddened areas were noted in treated animals. Abrasions applied prior to treatment did not affect the results. The acute dermal LD50 for undiluted Neodene 6 alpha olefin was reported as >2000 mg/kg in rabbits.
This study received a Klimisch score of 1 and is classified as reliable without restriction because it was conducted in accordance with OECD 402 and was GLP compliant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again