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EC number: 700-497-0
CAS number: -
Sprague-Dawley rats were acclimatized for 4 to 6 days prior to exposure.
Animals were housed 4/ cage with the number of cages limited to 4 per
exposure chamber. Food and water were givenad libitum, except
during exposure period. Animals were exposed to individual hydrocarbons
selected for the experiment in six different experiments. The
approximate concentration of the hydrocarbons (1 -alkenes andiso-alkanes)
tested was 100 parts per million. All exposures occurred during daytime
for 12 hours for 3 consecutive days. Concentrations of the hydrocarbons
was measured in blood, brain, liver, kidney and perirenal fat
immediately after 12 hour exposure on each exposure day, and 12 hours
after the last exposure had been completed. The animals were removed one
at a time from the exposure chamber and killed by decapitation. A
standard process, not described in the article, made it possible to
obtain blood and organ samples within 3 minutes of removal of animals
from the exposure chamber.
results indicated that 1-octene was efficiently absorbed in the blood
with extensive accumulation in the organs compared to the iso-alkanes. Accumulation
also was shown to increase with increasing carbon number. At
day 3, concentrations of 1-octene were 12.4±0.5, 69.7±4.0, 78.9±9.7,
139.3±23.4, 720±176 µmol/kg in the blood, brain, liver, kidney, and fat,
of 1-decene were 16.4±1.1, 138.1±2.7, 192.8±13.5, 162±22.9, and 2986±305
µmol/kg at day 3 in the blood, brain, liver, kidney, and fat,
of the 1-alkenes remained high in the fat even after the 12 hour
recovery period, with 226±85 µmol/kg of 1-octene and 1971±134 µmol/kg of
to the study authors, the extensive accumulation of 1-alkenes in the
blood and organs when compared to other hydrocarbons may have
toxicological significance and, therefore, products containing 1-alkenes
should be handled cautiously to minimize inhalation exposure.
on study design and results, this
study is classified as reliable with restrictions because while there is
no statement regarding whether this study was conducted according to GLP
or equivalent, the information provided indicates that this study was
conducted in a manner similar to OECD 417 guideline.
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