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EC number: 700-497-0 | CAS number: 1335202-82-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This study is classified as reliable with restrictions because while there is no statement regarding whether this study was conducted according to GLP or equivalent, the information provided indicates that this study was conducted in a similar manner to OECD 417 guideline.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This study is classified as reliable with restrictions because while there is no statement regarding whether this study was conducted according to GLP or equivalent, the information provided indicates that this study was conducted in a similar manner to OECD 417 guideline.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 417 (Toxicokinetics)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Though a GLP guideline is not specified in the study, the study was performed in a manner similar to the OECD 417 guideline.
- GLP compliance:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 1-Octene
- Substance type: C8 alpha olefin
- Analytical purity: 99% - Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Mollegaard A/S, L1 Skensved, Denmark
- Weight at study initiation: 150 to 200 grams
- Housing: 4 animals/cage
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: 4 to 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 +/- 1
- Humidity (%): 70 +/- 20 RH
- Photoperiod (hrs dark / hrs light): 10 hrs dark/14 hrs light
- Route of administration:
- inhalation
- Vehicle:
- other: air
- Details on exposure:
- TYPE OF INHALATION EXPOSURE: Whole body
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Conically shaped 0.7 cubic metre steel chambers with glass front door and walls
- Method of holding animals in test chamber: 4 animals/cage with 4 cages/chamber
- Source and rate of air: Source not provided; air rate at 5 m3/hr
- Concentration of test material in vehicle (if applicable): 100 parts per million in air
- Duration and frequency of treatment / exposure:
- All animals exposed for 12 hrs/day during daytime for 3 consecutive days.
- Remarks:
- Doses / Concentrations:
100 parts per million - No. of animals per sex per dose / concentration:
- Authors state that 4 animals/cage with a maximum of 4 cages per exposure chamber were used. A total of six separate experiments were performed. Specific details regarding number of animals used per experiment are not provided.
- Control animals:
- not specified
- Positive control reference chemical:
- Not applicable
- Details on study design:
- Details regarding dose selection or assignment of animals to the six experiments performed are not provided.
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled (delete / add / specify): Blood, brain, liver, kidney, and fat
- Time and frequency of sampling: Immediately after 12 hrs exposure on days 1, 2, and 3 of the exposure period and 12 hrs after cessation of last exposure on day 3
- Statistics:
- Information regarding statistical analysis not provided.
- Preliminary studies:
- 1-Octene showed efficient absorption in the blood with extensive accumulation in the organs as compared to the iso-alkanes. Accumulation also was shown to increase with increasing carbon number. At day 3, concentrations of 1-octene were 12.4±0.5, 69.7±4.0, 78.9±9.7, 139.3±23.4, 720±176 µmol/kg in the blood, brain, liver, kidney, and fat, respectively. Concentrations of the 1-alkenes remained high in the fat even after the 12 hour recovery period, with 226±85 µmol/kg of 1-octene. According to the study authors, the extensive accumulation of 1-alkenes in the blood and organs as compared to other hydrocarbons may have toxicological significance and, therefore, products containing 1-alkenes should be handled cautiously to minimize inhalation exposure.
- Details on absorption:
- 1-Octene was efficiently absorbed into the blood.
- Details on distribution in tissues:
- 1-Octene was distributed in the following manner in the male Sprague-Dawley rats: fat>kidney>liver>brain>blood following measurements taken aft12 hours on exposure days 1, 2, and 3. However distribution in tissues following measurements taken 12 hours after exposure had ceased, indicated that fat had the highest concentration of 1-octene followed by the liver.
- Details on excretion:
- Data not provided
- Metabolites identified:
- not specified
- Conclusions:
- Interpretation of results (migrated information): other: Several organs showed bioaccumulation during exposure and following exposure cessation. However, no data are provided for bioaccumulation potential several days after exposure ended.
According to the study authors, the extensive accumulation of 1-alkenes in the blood and organs as compared to other hydrocarbons may have toxicological significance and, therefore, products containing 1-alkenes should be handled cautiously to minimize inhalation exposure. - Executive summary:
Male Sprague-Dawley rats were acclimatized for 4 to 6 days prior to exposure. Animals were housed 4/ cage with the number of cages limited to 4 per exposure chamber. Food and water were givenad libitum, except during exposure period. Animals were exposed to individual hydrocarbons selected for the experiment in six different experiments. The approximate concentration of the hydrocarbons (1 -alkenes andiso-alkanes) tested was 100 parts per million. All exposures occurred during daytime for 12 hours for 3 consecutive days. Concentrations of the hydrocarbons was measured in blood, brain, liver, kidney and perirenal fat immediately after 12 hour exposure on each exposure day, and 12 hours after the last exposure had been completed. The animals were removed one at a time from the exposure chamber and killed by decapitation. A standard process, not described in the article, made it possible to obtain blood and organ samples within 3 minutes of removal of animals from the exposure chamber.
Experimental results indicated that 1-octene was efficiently absorbed in the blood with extensive accumulation in the organs compared to the iso-alkanes. Accumulation also was shown to increase with increasing carbon number. At day 3, concentrations of 1-octene were 12.4±0.5, 69.7±4.0, 78.9±9.7, 139.3±23.4, 720±176 µmol/kg in the blood, brain, liver, kidney, and fat, respectively. Concentrations of 1-decene were 16.4±1.1, 138.1±2.7, 192.8±13.5, 162±22.9, and 2986±305 µmol/kg at day 3 in the blood, brain, liver, kidney, and fat, respectively. Concentrations of the 1-alkenes remained high in the fat even after the 12 hour recovery period, with 226±85 µmol/kg of 1-octene and 1971±134 µmol/kg of 1-decene. According to the study authors, the extensive accumulation of 1-alkenes in the blood and organs when compared to other hydrocarbons may have toxicological significance and, therefore, products containing 1-alkenes should be handled cautiously to minimize inhalation exposure.
Based on study design and results, this study is classified as reliable with restrictions because while there is no statement regarding whether this study was conducted according to GLP or equivalent, the information provided indicates that this study was conducted in a manner similar to OECD 417 guideline.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 417 (Toxicokinetics)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Though a GLP guideline is not specified in the study, the study was performed in a manner similar to the OECD 417 guideline.
- GLP compliance:
- no
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 111-66-0
- Molecular formula:
- C8H16
- Reference substance name:
- 1-Octene
- IUPAC Name:
- 1-Octene
- Details on test material:
- - Name of test material (as cited in study report): 1-Octene
- Substance type: C8 alpha olefin
- Analytical purity: 99%
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 1-Octene
- Substance type: C8 alpha olefin
- Analytical purity: 99%
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Mollegaard A/S, L1 Skensved, Denmark
- Weight at study initiation: 150 to 200 grams
- Housing: 4 animals/cage
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: 4 to 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 +/- 1
- Humidity (%): 70 +/- 20 RH
- Photoperiod (hrs dark / hrs light): 10 hrs dark/14 hrs light
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- other: air
- Details on exposure:
- TYPE OF INHALATION EXPOSURE: Whole body
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Conically shaped 0.7 cubic metre steel chambers with glass front door and walls
- Method of holding animals in test chamber: 4 animals/cage with 4 cages/chamber
- Source and rate of air: Source not provided; air rate at 5 m3/hr
- Concentration of test material in vehicle (if applicable): 100 parts per million in air
- Duration and frequency of treatment / exposure:
- All animals exposed for 12 hrs/day during daytime for 3 consecutive days.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 parts per million
- No. of animals per sex per dose / concentration:
- Authors state that 4 animals/cage with a maximum of 4 cages per exposure chamber were used. A total of six separate experiments were performed. Specific details regarding number of animals used per experiment are not provided.
- Control animals:
- not specified
- Positive control reference chemical:
- Not applicable
- Details on study design:
- Details regarding dose selection or assignment of animals to the six experiments performed are not provided.
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled (delete / add / specify): Blood, brain, liver, kidney, and fat
- Time and frequency of sampling: Immediately after 12 hrs exposure on days 1, 2, and 3 of the exposure period and 12 hrs after cessation of last exposure on day 3
- Statistics:
- Information regarding statistical analysis not provided.
Results and discussion
- Preliminary studies:
- 1-Octene showed efficient absorption in the blood with extensive accumulation in the organs as compared to the iso-alkanes. Accumulation also was shown to increase with increasing carbon number. At day 3, concentrations of 1-octene were 12.4±0.5, 69.7±4.0, 78.9±9.7, 139.3±23.4, 720±176 µmol/kg in the blood, brain, liver, kidney, and fat, respectively. Concentrations of the 1-alkenes remained high in the fat even after the 12 hour recovery period, with 226±85 µmol/kg of 1-octene. According to the study authors, the extensive accumulation of 1-alkenes in the blood and organs as compared to other hydrocarbons may have toxicological significance and, therefore, products containing 1-alkenes should be handled cautiously to minimize inhalation exposure.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- 1-Octene was efficiently absorbed into the blood.
- Details on distribution in tissues:
- 1-Octene was distributed in the following manner in the male Sprague-Dawley rats: fat>kidney>liver>brain>blood following measurements taken aft12 hours on exposure days 1, 2, and 3. However distribution in tissues following measurements taken 12 hours after exposure had ceased, indicated that fat had the highest concentration of 1-octene followed by the liver.
- Details on excretion:
- Data not provided
Metabolite characterisation studies
- Metabolites identified:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: Several organs showed bioaccumulation during exposure and following exposure cessation. However, no data are provided for bioaccumulation potential several days after exposure ended.
According to the study authors, the extensive accumulation of 1-alkenes in the blood and organs as compared to other hydrocarbons may have toxicological significance and, therefore, products containing 1-alkenes should be handled cautiously to minimize inhalation exposure. - Executive summary:
Male Sprague-Dawley rats were acclimatized for 4 to 6 days prior to exposure. Animals were housed 4/ cage with the number of cages limited to 4 per exposure chamber. Food and water were givenad libitum, except during exposure period. Animals were exposed to individual hydrocarbons selected for the experiment in six different experiments. The approximate concentration of the hydrocarbons (1 -alkenes andiso-alkanes) tested was 100 parts per million. All exposures occurred during daytime for 12 hours for 3 consecutive days. Concentrations of the hydrocarbons was measured in blood, brain, liver, kidney and perirenal fat immediately after 12 hour exposure on each exposure day, and 12 hours after the last exposure had been completed. The animals were removed one at a time from the exposure chamber and killed by decapitation. A standard process, not described in the article, made it possible to obtain blood and organ samples within 3 minutes of removal of animals from the exposure chamber.
Experimental results indicated that 1-octene was efficiently absorbed in the blood with extensive accumulation in the organs compared to the iso-alkanes. Accumulation also was shown to increase with increasing carbon number. At day 3, concentrations of 1-octene were 12.4±0.5, 69.7±4.0, 78.9±9.7, 139.3±23.4, 720±176 µmol/kg in the blood, brain, liver, kidney, and fat, respectively. Concentrations of 1-decene were 16.4±1.1, 138.1±2.7, 192.8±13.5, 162±22.9, and 2986±305 µmol/kg at day 3 in the blood, brain, liver, kidney, and fat, respectively. Concentrations of the 1-alkenes remained high in the fat even after the 12 hour recovery period, with 226±85 µmol/kg of 1-octene and 1971±134 µmol/kg of 1-decene. According to the study authors, the extensive accumulation of 1-alkenes in the blood and organs when compared to other hydrocarbons may have toxicological significance and, therefore, products containing 1-alkenes should be handled cautiously to minimize inhalation exposure.
Based on study design and results, this study is classified as reliable with restrictions because while there is no statement regarding whether this study was conducted according to GLP or equivalent, the information provided indicates that this study was conducted in a manner similar to OECD 417 guideline.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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