Registration Dossier
Registration Dossier
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EC number: 217-090-4 | CAS number: 1738-25-6
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: limited documentation and animal number
Data source
Reference
- Reference Type:
- publication
- Title:
- Reproduction in rats fed Lathyrus peas or aminonitriles
- Author:
- F.W.Stamler
- Year:
- 1 955
- Bibliographic source:
- Proc. Soc. Exp. Biol. Med., 90, 294-298 (1955)
Materials and methods
- Principles of method if other than guideline:
- 2 pragnant Rats recieved a diet containing 0.3% 3-dimethylaminopropionitrile
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-dimethylaminopropiononitrile
- EC Number:
- 217-090-4
- EC Name:
- 3-dimethylaminopropiononitrile
- Cas Number:
- 1738-25-6
- Molecular formula:
- C5H10N2
- IUPAC Name:
- 3-(dimethylamino)propanenitrile
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Route of administration:
- oral: feed
- Details on exposure:
- no further information
- Analytical verification of doses or concentrations:
- not specified
- Details on mating procedure:
- no details
- Duration of treatment / exposure:
- 17 days
- Frequency of treatment:
- once daily
- Duration of test:
- 17 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.3 %
Basis:
nominal in diet
- No. of animals per sex per dose:
- 2
- Control animals:
- no
Examinations
- Maternal examinations:
- no
- Ovaries and uterine content:
- resuptions were evaluated
- Fetal examinations:
- no
- Statistics:
- no
- Indices:
- no data
- Historical control data:
- no data
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:no data
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects
Details on embryotoxic / teratogenic effects:
no embryotoxicity, teratogenicity was not examined
Effect levels (fetuses)
- Dose descriptor:
- NOEL
- Effect level:
- 3 000 ppm (nominal)
- Basis for effect level:
- other: embryotoxicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
