Registration Dossier
Registration Dossier
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EC number: 277-452-2 | CAS number: 73398-61-5
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 177.79 mg/m³
DNEL related information
- Overall assessment factor (AF):
- 25
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 25.21 mg/kg bw/day
DNEL related information
- Overall assessment factor (AF):
- 100
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
The long-term DNELs are based on a 90 -day oral feeding study performed in F344/N rats with Castor oil (CAS-No. 8001 -79 -4) as a Read Across substance. The NOAEL in this study was found to be 5000 mg/kg bw/d (highest dose tested).
The molecular weight of Castor oil (CAS 8001 -79 -4) is 933.43.
The molecular weight of Glycerides, mixed decanoyl and octanoyl (CAS 73398 -61 -5) is 470.69 -554.85.
With regard to the molecular weight ratio of both substances the NOAEL used for the calculation of DNELs was assumed to be 2521 mg/kg bw/d.
The assessment factors were chosen according to ECHA Guidance document R.8 (Characterisation of dose [concentration]-response for human health, May 2008.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 43.84 mg/m³
DNEL related information
- Overall assessment factor (AF):
- 50
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 12.61 mg/kg bw/day
DNEL related information
- Overall assessment factor (AF):
- 200
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 12.61 mg/kg bw/day
DNEL related information
- Overall assessment factor (AF):
- 200
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Summarizing all available information on medium chain triglycerides, there were no reasonable evidence to suspect a hazard to the public. The assessment factors were chosen according to R.8 ECHA Guidance document.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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