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EC number: 277-452-2 | CAS number: 73398-61-5
After single bolus injection of 10 g triglycerides, human serum triglyceride concentrations measured 1 minute after injections were increased to 373 % and 320 %, respectively (using two different lipid emulsions). Maximum measured serum triglyceride concentrations were 601 mg/dL (Lipidol ⅓ MCT 20%) and 630 mg/dL (Lipidol ½ MCT 20%) after initial values of 128 - 150 mg/dL. Elimination half-times were between 15.1 minutes (kel4.6 % per min) for Lipidol ½ MCT 20% and 27.9 minutes. (kel2.48 % per min) for Lipidol ⅓ MCT 20%.
Short time infusion - 50 g triglycerides in 30 minutes:
Maximum measured human serum triglyceride concentrations were 1992 mg/dL (Lipidol ⅓ MCT 20%) and 1964 mg/dL (Lipidol ½ MCT 20%) after initial values of 108 - 128 mg/dL. Elimination half-times were between 46.2 minutes (kel1.5 % per min) for Lipidol ½ MCT 20% and 54.6 minutes. (kel1.27 % per min) for Lipidol ⅓ MCT 20%.
After infusion of higher triglyceride concentrations a high increase of the elimination half-times was observed:
12 h infusion - 0.1 g triglycerides/kg bw/h:
Within 3-4 hours maximum measured human serum triglyceride concentrations were 236 mg/dL (Lipidol ⅓ MCT 20%) and 287 mg/dL (Lipidol ½ MCT 20%) after initial values of 100 - 120 mg/dL. With both lipid emulsions a dynamic equilibrium was observable with serum triglyceride concentrations of 200 - 250 mg/dL. After 9 hours a steady state concentration of 177-200 mg/dL serum triglycerides was measured.
8 h infusion - 0.25 g triglycerides/kg bw/h:
No dynamic equilibrium could be observed. The elimination capacity was exceeded. The maximum measured human serum triglyceride concentrations were 1449 mg/dL (Lipidol ⅓ MCT 20%) and 1305 mg/dL (Lipidol ½ MCT 20%) after initial values of 94.3 and 75.8 mg/dL. 4 hours after termination of infusion, the triglyceride concentrations were still 4-5 fold of the initial values, indicating a slow elimination.
After infusion of both lipid emulsions a significant increase of fatty acid concentrations was measured, indicating a rapid hydrolysis of Triglycerides after intravenous application. After infusion of high dose triglycerides a remarkable increase of caprylic acid and decanoic acid concentrations were measured, clearly exceeding physiologic reference values.
After high dose infusion some subjects stated sickness.
Measured ketone body concentrations were proportionally higher with higher MCT content in lipid emulsions.
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