Registration Dossier
Registration Dossier
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EC number: 457-670-6 | CAS number: 157859-20-6
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Tri(isopropyl)silyl acrylate hydrolyses very rapidly in solution. The silanol hydrolysis product has low solubility in water and relatively high log Kow. The limiting concentration in water is low due to expected tendency to dimerise in solution. Some aquatic toxicity is to be expected and it is possible that short term testing may not have fully captured the potential for chronic effects. However, testing in fish is not appropriate for the following reasons:
· Fish were the least sensitive trophic level in short-term studies. The most sensitive trophic level in short-term tests is algae, for which EC50 and NOEC values were approximately 70 times lower than the corresponding values in fish, in the key short-term studies.
· The EC50 value for invertebrates is approximately 10 times lower than the LC50 value in fish, in the key short-term studies.
· A long-term invertebrate study using a pre-hydrolysed sample has been conducted. The long-term invertebrate and 72-hour algal studies should together be adequate to refine the PNEC and fulfil the data requirements for long-term toxicity.
· The aquatic RCR is low (<1).
· The substance is already classified Chronic Category 2 in accordance with Regulation (EC) No. 1272/2008 (as amended) based on the algal effects data.
In light of the above considerations, it is not appropriate or useful to propose to conduct new long-term testing in fish.
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