Registration Dossier
Registration Dossier
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EC number: 457-670-6 | CAS number: 157859-20-6
Endpoint summary
Administrative data
Description of key information
The key study for acute oral toxicity study in rats was conducted according to OECD test guideline 423 and in compliance with GLP. The LD50 identified for tri(isopropyl)silyl acrylate was >2000 mg/kg bw (RCC 2004a).
The key study for acute dermal toxicity study in rats, was conducted according to OECD test guideline 402 and in compliance with GLP. The LD50 identified for tri(isopropyl)silyl acrylate was >2000 mg/kg bw (RCC 2004b).
In accordance with Column 2 of REACH Annex VIII, the acute toxicity study via the inhalation route (required in Section 8.5.2) does not need to be conducted as reliable data via the oral and dermal routes are available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The key data are the only available studies for tri(isopropyl)silyl acrylate.
The key study for acute oral toxicity (RCC, 2004a) was conducted to OECD test guideline 423 and in compliance with GLP. Female rats were treated by oral gavage with a dose of 2000 mg/kg bw in PEG 300 and observed for 14 days. All of the animals survived until the end of the study but slight to moderate ataxia was observed at the 2-hour observation and up to test day 2 in one animal and slight ataxia in four further animals at 5 hours post-dosing. The gross pathology revealed no macroscopic findings.
The key study for acute dermal toxicity (RCC 2004b) was conducted to OECD test guideline 402 and in compliance with GLP. In this study, a 24-hour semi-occlusive, dermal application of test material was applied to rats. The animals were observed over a period of 14 days, and the LD50 identified was >2000 mg/kg bw (RCC 2004b). The clinical signs included very slight erythema observed in all male and female animals on test day 2 which persisted in all males up to test day 4 and in two females up to test day 6 and 7 respectively. Slight crusts were noted on one male on test day 5, in another male from test day 5 to 8 and on one female on test day 8. No macroscopic findings observed at necropsy.
Justification for classification or non-classification
Based on available data on the acute toxicity of the registered substance, tri(isopropyl)silyl acrylate, no classification is required in accordance with Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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