Registration Dossier
Registration Dossier
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EC number: 213-063-6 | CAS number: 921-03-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- before 1982
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Handbook data
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicometric Parameters of industrial toxic chemicals under single exposure
- Author:
- Izmerov, N.F., Sanotsky, I.V., Sidorov, K.K.
- Year:
- 1 982
- Bibliographic source:
- United Nations Environment Program et al. , Centre of International Projects, Moscow, 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
- Test type:
- other: not reported
- Limit test:
- no
Test material
- Reference substance name:
- 1,1,3-trichloroacetone
- EC Number:
- 213-063-6
- EC Name:
- 1,1,3-trichloroacetone
- Cas Number:
- 921-03-9
- Molecular formula:
- C3H3Cl3O
- IUPAC Name:
- 1,1,3-trichloropropan-2-one
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Details on inhalation exposure:
- no data
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 2 h
- Concentrations:
- not mentioned
- No. of animals per sex per dose:
- no data
- Control animals:
- no
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
- Preliminary study:
- no data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 390 mg/m³ air
- Exp. duration:
- 2 h
- Remarks on result:
- other: The LC50 for mice is reported to be 360 */- 44 mg/m3.
- Mortality:
- not reported
- Clinical signs:
- other: not reported
- Body weight:
- not reported
- Gross pathology:
- not reported
- Other findings:
- not reported
Applicant's summary and conclusion
- Interpretation of results:
- highly toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Substance is very toxic if inhaled.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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