1,1,3-trichloroacetone

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1989

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to OECD Test Guidance

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1990

Report date:

1998

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

Deviations:

no

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

1,1,3-trichloroacetone

EC Number:

213-063-6

EC Name:

1,1,3-trichloroacetone

Cas Number:

921-03-9

Molecular formula:

C3H3Cl3O

IUPAC Name:

1,1,3-trichloropropan-2-one

Details on test material:

- Name of test material (as cited in study report): 1,1,3-Trichloroacetone
- Physical state: liquid
- Analytical purity: 97%
- Impurities (identity and concentrations): not reported

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
not applicable

Sampling and analysis

Analytical monitoring:

no

Details on sampling:

not applicable

Test solutions

Vehicle:

no

Details on test solutions:

not reported

Test organisms

Test organisms (species):

Oncorhynchus mykiss (previous name: Salmo gairdneri)

Details on test organisms:

TEST ORGANISM
- Common name: rainbow trout
- Source: laboratory reared population
- Age at study initiation (mean and range, SD): juvenile


ACCLIMATION
- Acclimation period:appropriate
- Acclimation conditions (same as test or not): same

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Post exposure observation period:

not reported

Test conditions

Hardness:

4.5 mg CaCO3/l

Test temperature:

15 °C

pH:

6.4

Dissolved oxygen:

not reported

Salinity:

not reported

Nominal and measured concentrations:

up to 25 mg/l

Details on test conditions:

TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: glas
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Biomass loading rate: 0.55 g/l


TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Vancouver tap water
- Chlorine: < 0.01 mg/l
- Alkalinity: 3.8 mg CaCO3/l
- Conductivity: 15 µmhos/cm
- Culture medium different from test medium: no


OTHER TEST CONDITIONS
- Photoperiod: 12/12

Reference substance (positive control):

yes

Remarks:

sodium pentachlorophenate

Results and discussion

Effect concentrations

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

2.3

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: 95% CL 2 to 3 mg/l

Details on results:

not observed

Results with reference substance (positive control):

- Results with reference substance valid? yes
- Mortality: yes
-LC50 96.7 to 104.9 µg/l

Reported statistics and error estimates:

no

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

1,1,3-Trichloroacetone is toxic for fish under the conditions used.

Executive summary:

1,1,3-Trichloroacetone was assessed for its toxic properties in a static acute fish toxicity test. Groups of 10 fish were exposed to the test item up to concentrations of 25 mg/l of Vancouver tap water. Two replicates were used for each concentration. The positive control (sodium pentachlorophenate) showed an LC50 of 96.7 to 104.9 µg/l. The LC50 for the test item is 2.3 mg/l. 1,1,3-Trichloroacetone is toxic for fish under the conditions used.