Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
before August 1987
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: comparable to OECD Guidelines, some details lacking

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1988
Report Date:
1988

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1,1,3-Trichloroacetone (1,1,3-TCA)
- Substance type: chemical
- Physical state: not reported
- Analytical purity: not reported

Test animals

Species:
mouse
Strain:
B6C3F1
Sex:
male/female
Details on test animals and environmental conditions:
not given in report

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Emulphor EL-620
Details on oral exposure:
not given
Doses:
not given in report
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
Test was performed as a dose range finder for the in vivo micronucleus test.
Statistics:
not stated in report

Results and discussion

Preliminary study:
not available
Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
35 mg/kg bw
95% CL:
19 - 59
Sex:
female
Dose descriptor:
LD50
Effect level:
26 mg/kg bw
95% CL:
10 - 45
Mortality:
not reported
Clinical signs:
not reported
Body weight:
not reported
Gross pathology:
not reported
Other findings:
not reported

Applicant's summary and conclusion

Interpretation of results:
toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Substance is toxic via oral application under the conditions used.
Executive summary:

In an oral acute toxicity test used as a dose range finder for a micronucleus assay in vivo, the test item turned out to have a LD 50 for mice of 35 mg/kg bw for males and 26 mg/kg bw for females.