Biphenyl-4,4'-diol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23-07-2012 to 03-08-2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Proprietary GLP study report.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Specific details on test material used for the study:

Biphenyl-4,4’-diol / CAS 92-88-6

Key result

Water solubility:

33.7 mg/L

Temp.:

20 °C

pH:

6.5

Water Solubility Results at 20 °C for 4,4-Biphenol

 

Sample	Replicate No.	4,4-Biphenol [mg/L]
		Concentration^2)	Mean
24 h	1	33.8	33.7
	2	33.7
48 h	1	32.5	33.4
	2	34.4
72 h	1	35.2	34.0
	2	32.9
Mean (24 - 72 h)			33.7
Deviation [%]^1)			1.8

1)            Calculated according to Formula, Deviation (%) = 100 x (max value - min value) / min value.

2)            Mean value of two injections, dilution factor of 2 taken into account

The analytical method (HPLC-DAD, external standard) for the determination of the test item 4,4-Biphenol was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity.

Conclusions:

The solubility of the test item was determined to be 33.7 mg/L (pH 6.5) at 20 +/- 0.5 °C. The substance is considered pratically insoluble (solubility < 0.1 g/L)

Executive summary:

The water solubility of 4,4-Biphenol was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 440/2008, Method A.6 from 2012-07-23 to 2012-08-03 at Dr.U.Noack-Laboratorien, 31157 Sarstedt, Germany.

The decision for employing the flask method was based on preliminary testing (non GLP), where a solubility of approximately 10 mg/L was observed.

The solubility of the test item 4,4-Biphenol was determined using the flask method at 20 ± 0.5 °C with preincubation at 30 ± 0.5 °C.

The analytical method (HPLC-DAD, external standard) for the determination of the test item 4,4-Biphenol was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity.

The water solubility of 4,4-Biphenol was determined to be 33.7 mg/L (20 °C, pH 6.5).

Description of key information

The solubility of the test item was determined to be 33.7 mg/L (pH 6.5) at 20 +/- 0.5 °C.

Key value for chemical safety assessment

Water solubility:

33.7 mg/L

at the temperature of:

20 °C