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EC number: 306-084-8
CAS number: 95912-88-2
Taking all available information into account the LCAE category members are unlikely to pose a risk for sediment organisms and testing is thus omitted.
No experimental data evaluating the toxicity to sediment organisms
are available for the LCAE category members.Only negligible releases
into surface waters from sewage treatment plants are expected to take
place due to: a) the ready biodegradability and b) the high adsorption
properties of this substance, resulting in an effective removal in
sewage treatment plants. Therefore chronic exposure of sediment
organisms is unlikely.Furthermore, the substance is not toxic to aquatic
organisms up to the limit of water solubility. In addition, available
data indicate, that the LCAE category members are not bioaccumulative.
Based on the available information, toxicity to sediment organisms is
not expected to be of concern.
Intrinsic properties and fate
All LCAE category members are readily biodegradable. According to
the Guidance on information requirements and chemical safety assessment,
Chapter R.7b, readily biodegradable substances can be expected to
undergo rapid and ultimate degradation in most environments, including
biological Sewage Treatment Plants (STPs) (ECHA, 2012b). Therefore,
after passing through conventional STPs, only low concentrations of
these substances are likely to be (if at all) released into the
Furthermore, the LCAE category members exhibit a log Koc value of
> 5 and are poorly water soluble (< 1 mg/L or even < 0.05 mg/L). The
Guidance on information requirements and chemical safety assessment,
Chapter R7.b (ECHA, 2012b) states that once insoluble chemicals enter a
standard STP, they will be extensively removed in the primary settling
tank and fat trap and thus, only limited amounts will get in contact
with activated sludge organisms. Nevertheless, once this contact takes
place, these substances are expected to be removed from the water column
to a significant degree by adsorption to sewage sludge (Guidance on
information requirements and chemical safety assessment, Chapter R.7a,
(ECHA,2012a)) and the rest will be
extensively biodegraded (due to ready biodegradability). Thus,
discharged concentrations of these substances into the aqueous/sediment
compartment are likely to be negligible.
Considering this one can assume that the availability of the LCAE
category members in the sediment environment is very low, which reduces
the probability of chronic exposure of sediment organisms in general.
Aquatic ecotoxicity data
Available acute data with fish, aquatic invertebrates and algae as
well as chronic aquatic toxicity tests aquatic invertebrates and algae
showed that no adverse effects occurred in the range of the water
solubility of the LCAE category members (< 1 mg/L or even < 0.05 mg/L).
Moreover, no toxic effects on activated sludge microorganisms were
observed. The results obtained indicate that the LCAE category members
are likely to show no toxicity to sediment organisms as well. It is not
expected that results from additional studies with sediment organisms
will lie out of the overall ecotoxicological profile of the category.
After absorption, the LCAE category members are expected to be
enzymatically hydrolyzed by carboxylesterases yielding the corresponding
alcohol and fatty acid. QSAR estimations using BCFBAF v3.0 support the
expected rapid biotransformation of this substance with BCF/BAF values
of 0.89 - 14.07 and 0.90 - 314 L/kg were obtained, respectively. The
metabolism of the hydrolysis products is well established and not of
concern in terms of bioaccumulation (for further information see chapter
5.3 of the technical dossier). Summarizing, the LCAE category members
are expected to be rapidly hydrolyzed to the respective fatty acid and
fatty alcohol. Both hydrolysis products are supposed to be satisfactory
metabolized in aquatic organisms. Therefore, the potential for
bioaccumulation is low.
Due to its readily biodegradable nature, extensive degradation of
the LCAE category members in conventional STPs will take place and only
low concentrations are expected to be released (if at all) into the
environment. Once present in the aquatic compartment, further
biodegradation will occur and, due to the high log Kow, low water
solubility and high adsorption potential, the LCAE category members will
be bioavailable to sediment organisms mainly via feed and contact with
suspended organic particles. After uptake by sediment species, extensive
and fast biotransformation of the substance by carboxylesterases into
the corresponding fatty acid and alcohol are expected. The supporting
BCF/BAF values estimated with the BCFBAF v3.01 program, Arnot-Gobas
model including biotransformation, also indicate that this substance
will not be bioaccumulative (all well below 2000). Furthermore, all
available aquatic toxicity data show that no effects occur up to the
limit of water solubility. Therefore, the LCAE category members are
unlikely to pose a risk for sediment organisms and testing is thus
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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