2,2'-Methylenebis(4-aminophenol) dihydrochloride

Toxicity to microorganisms

Administrative data

Endpoint:

toxicity to microorganisms

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study and GLP

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2003

Report date:

2003

Materials and methods

Principles of method if other than guideline:

Method: DIN 38412, Teil 8

GLP compliance:

yes

Test material

Reference

Name:

Unnamed

Type:

Constituent

Details on test material:

IUCLID4 Test substance: as prescribed by 1.1 - 1.4

Substance-No.: SAT 020874
Batch-No.: Ro 3962-88

Sampling and analysis

Analytical monitoring:

not specified

Test solutions

Vehicle:

not specified

Test organisms

Test organisms (species):

Pseudomonas putida

Study design

Test type:

static

Water media type:

not specified

Limit test:

no

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

16 h

Dose descriptor:

EC10

Effect conc.:

4 mg/L

Effect concentrations 2

Duration:

16 h

Dose descriptor:

EC50

Effect conc.:

11 mg/L

Any other information on results incl. tables

RS-Freetext:
16h-EC10 =  4 mg/L (95%-CI: 2,8 - 5,O mg/L)
16h-EC50 = 11 mg/L (95%-CI: 10 - 14 mg/L)

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Executive summary:

Ro 1525 was tested according to Method: DIN 38412, Teil 8 and reached after 16 hours an EC50 of 11 mg/l related to active substance.