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EC number: 440-850-3 | CAS number: 27311-52-0
This study was performed to investigate the potential of Ro 1525 to induce gene mutations
according to the plate incorporation test (experiment I) and the pre-incubation test
(experiment II) using the Salmonella typhimurium strains TA 1535, TA 1537, TA 98,
TA 100. and TA 102.
The assay was performed in two independent experiments both with and without h e r
microsomal activation. Each concentration, including the controls, was tested in triplicate.
The test article was tested at the following concentrations:
33; 100; 333; 1000; 2500; and 5000 pg/plate
The background growth was reduced at concentrations as low as 333 pglplate in the first
and at 100 pg/plate and above in the second experiment without metabolic activation.
No substantial increase in revertant colony numbers of any of the five tester strains was
observed following treatment with Ro 1525 at any dose level, neither in the presence nor
absence of metabolic activation (S9 mix). There was also no tendency of higher mutation
rates with increasing concentrations in the range below the generally acknowledged border
of biological relevance.
Appropriate reference mutagens were used as positive controls and showed a distinct increase
of induced revertant colonies.
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