Registration Dossier

Physical & Chemical properties

Additional physico-chemical information

Administrative data

Endpoint:
additional physico-chemical information
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study and GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report Date:
2002

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
yes
Endpoint investigated:
other: Stability test in M4 test medium

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Results and discussion

Results:
The test item Ro 1525 is not stable in the Medium M4 for the daphnia test. Irrespective of the usage concentration (100 mg/l to 3 mg/l), the test item can be observed to react directly as soon as it comes into contact with the test medium. This can be demonstrated by determining the concentration of the test item as a function ot time by liquid chromatography. The formation of an insoluble precipitate can be observed as the concentration of the test item decreases. After ony 24 hours the test item can no longer be detected analytically in the M4 test medoum, irrespective of its inital concentration (detection limit 1 mg/l). A caomparison with Milli-Q water shows that the chemical reactions with lead to the reduction of the test item concentration are catalyzed by constituents of the M4 test medium.

Any other information on results incl. tables

ro 1525 
 

Applicant's summary and conclusion

Conclusions:
The test item Ro 1525 is not stable in the Medium M4 for the daphnia test. Irrespective of the usage concentration (100 mg/l to 3 mg/l), the test item can be observed to react directly as soon as it comes into contact with the test medium. This can be demonstrated by determining the concentration of the test item as a function ot time by liquid chromatography. The formation of an insoluble precipitate can be observed as the concentration of the test item decreases. After ony 24 hours the test item can no longer be detected analytically in the M4 test medoum, irrespective of its inital concentration (detection limit 1 mg/l). A caomparison with Milli-Q water shows that the chemical reactions with lead to the reduction of the test item concentration are catalyzed by constituents of the M4 test medium.