Registration Dossier
Registration Dossier
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EC number: 273-708-2 | CAS number: 69011-71-8 A scum formed on the surface of molten aluminum and molten aluminum alloys.
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
- Dose descriptor:
- LOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Workers - Hazard for the eyes
Additional information - workers
- Duration of exposure: The default assessment factor for extrapolation of exposure duration from sub-chronic to chronic exposure is 2 (ECHA Guidance Document R.8 p. 38). The duration of the study in question is longer than a standard sub-chronic but shorter than a standard chronic, nevertheless this factor has been chosen
- Interspecies difference: The default assessment factor for interspecies differences for local effects on the respiratory tract is 2.5 ECHA Guidance Document R.8 p. 38).
- Intraspecies difference: The default assessment factor for intraspecies differences is 5 ECHA Guidance Document R.8 p. 38). Inhalable fraction: LOAEC calculated on fine aluminium dust (90% < 4μm) whereas aluminium dross consists of only 11% inhalable fraction (Smeykal, 2010). A final DNEL on total dust is extrapolated by division of DNEL by 0.11 Inhalable fraction: LOAEC calculated on fine aluminium dust (90% < 4μm) whereas aluminium dross consists of only 11% inhalable fraction (Smeykal, 2010). A final DNEL on total dust is extrapolated by division of DNEL by 0.11
Descriptor choice
From the available data the most appropriate choice is the result of Gross et al, 1973 on subchronic toxicity of aluminium metal.
Corrected dose descriptor
The descriptor has been corrected according to ECHA Guidance Document R.8 p 27
Assessment factors
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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